RRML - Evaluation of Osteoblastic/ Osteoclastic Activity in Postmenopausal Osteoporosis

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Nr. 20(2)/2012

Evaluation of Osteoblastic/ Osteoclastic Activity in Postmenopausal Osteoporosis

Camelia V. Gurban, Melania Balas, Ioana Zosin, Daliborca C. Vlad, Victor Dumitrascu

Abstract:

Background: In postmenopausal osteoporosis, bone loss is due to an increased bone resorption with an inadequately increased bone formation. The aim of this study was to evaluate the serum levels of bone markers implicated in the bone remodelling process. The resorption markers were represented by: receptor activator of nuclear factor-ĸB ligand (RANKL), while bone formation markers were represented by: osteoprotegerin (OPG), estradiol (E2) and zinc ions (Zn(2+)). Materials and methods: The study included 134 women with postmenopausal osteoporosis and 68 postmenopausal women without osteoporosis, as a control group. The serum levels of the discussed markers were measured by the enzyme-linked immunosorbent assay (ELISA) technique. Serum zinc ions concentrations were determined using the flame atomic absorption spectrometry (FAAS) technique. Bone mineral density (BMD) was measured using the dual energy X-ray absorptiometry (DXA) technique with the assessment of T score. Results: The serum levels of sRANKL were significantly higher in the postmenopausal osteoporosis group vs. the control group (p<0.0001). E2 and OPG levels in these subjects were significantly decreased as compared to controls (p<0.0001; respectively p<0.0001). The Zn(2+)serum levels were lower in the postmenopausal osteoporosis group (p<0.0001) vs. the control group. Conclusions: In postmenopausal osteoporosis the OPG/sRANKL ratio was lower than 1.0, secondary to the increasing osteoclastogenesis. Bone resorption begins gradually and outruns the new bone formation rhythm, this fact being associated with low BMD.

Keywords: postmenopausal osteoporosis,bone mineral density,bone markers.

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Gurban CV, Balas M, Zosin I, Vlad DC, Dumitrascu V. Evaluation of Osteoblastic/ Osteoclastic Activity in Postmenopausal Osteoporosis. Rev Romana Med Lab. 2012;20(2):143-50