RRML - Anti-oxidized low-density lipoprotein autoantibody, IL-1α, TNF α - cardiac risk markers
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Dr. Adrian Man
   
 
Nr. 11(2)/2008
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Anti-oxidized low-density lipoprotein autoantibody, IL-1α, TNF α - cardiac risk markers

Felicia Sfrijan, Mădălina Golieanu, Camelia Gurban, Doina Drugărin


Abstract:

Background: Evidence had been provided that about several interaction between inflammation and oxidized low-density lipoprotein-oxLDL within the artery wall so that the lipid hypothesis and the response to injury hypothesis are considered different aspects of a single pathogenic pathway. Objective: This study was conducted to analyse the correlation between serum level of proinflammatory cytokines IL-1α and TNF α and anti-oxidized low-density lipoprotein autoantibody (oLAB) in patients with coronary atherosclerosis and to demonstrate implication of immune-inflammatory mechanisms in progression of atherosclerotic lesion. Material and methods: Samples were obtained from patients with acute myocardial infarction-AMI (70), unstable angina-UA (40), stable angina-SA (50) and from healthy subjects (40). ELISA assay was used for quantification of serum levels of IL-1α, TNF α and oLAB. Results: Patients with AMI and UA had significantly grown serum levels of IL-1α (p<0.05) and TNF α (p<0.05) compared with the healthy group. The SA group differentiates from the healthy group only through grown serum levels of TNF α (p<0.001). Significantly increased levels of oLAB appear to the AMI and UA group (p<0.05). There is a strong correlation (r>0.6) between serum levels of proinflammatory cytokines and oLAB in the AMI group and a variable correlation of these parameters in UA and SA a groups. Conclusions: Increased levels of proinflammatory cytokines confirm the fact that the inflammatory reaction appear precocious in atherosclerotic lesion and influence the progress and the stability of plaque, and the correlation with immune markers of oxLDL may be an indicator for the prediction of the cardiac risk.

Keywords: proinflammatory cytokines,anti-oxidized low-density lipoprotein autoantibody,atherosclerosis

 
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How to cite
Sfrijan F, Golieanu M, Gurban C, Drugărin D. Anti-oxidized low-density lipoprotein autoantibody, IL-1α, TNF α - cardiac risk markers. Rev Romana Med Lab. 2008;11(2):21-8