RRML - Effects of miR-99a on the migration and proliferation of glioma cells

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Nr. 26(2)/2018 DOI:10.2478/rrlm-2018-0005

Research article

Effects of miR-99a on the migration and proliferation of glioma cells

Yifan Xu, Tianyu Lu, Wu Xu, Yuxiang Dai, Weibang Liang, Wei Jin

Correspondence should be addressed to: Weibang Liang

Abstract:

Background: To evaluate the effects of miR-99a on the migration and proliferation of glioma cells. Materials and Methods: Glioma cell line LN229 with stable up-regulation of miR-99a was constructed by transfection of hsa-miR-99a mimics, and cells with stable miR-99a knock-down were established by transfection of hsa-miR-99a inhibitor. The proliferation capacities of two groups were detected by the MTT assay, and their migration capacities were detected by the scratch assay. Results: LN229 cells with stable up-regulation and knock-down of miR-99a were successfully constructed. Up-regulating miR-99a inhibited the proliferation and migration of glioma cells, but knocking down this gene promoted their proliferation and migration. Conclusion: MiR-99a significantly affected the proliferation and migration of glioma cells, as a potentially eligible target for glioma therapy.

Keywords: miR-99a, migration, proliferation, glioma

Received: 21.8.2017
Accepted: 10.1.2018
Published: 15.4.2018

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Xu Y, Lu T, Xu W, Dai Y, Liang W, Jin W. Effects of miR-99a on the migration and proliferation of glioma cells. Rev Romana Med Lab. 2018;26(2):145-52. DOI:10.2478/rrlm-2018-0005