RRML - Bone status and aortic calcifications in chondrocalcinosis patients
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- May 2020 -
 
Multiplex ligation-dependent p... 23
Romanian Review of Laboratory ... 14
The predictive role of platele... 14
Bone status and aortic calcifi... 12
Total antioxidant status as ma... 11
Cardiotoxicity - the first cau... 10
Implications of visfatin genet... 9
Genetic variability of ANG2 -3... 8
Levels of lactoferrin, lysozym... 7
Relationships between serum pr... 5

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 28(2)/2020 DOI:10.2478/rrlm-2020-0019
XML
TXT

Research article

Bone status and aortic calcifications in chondrocalcinosis patients

Paulina Vele, Ciprian Nicolae Silaghi, Laura Otilia Damian, Siao-Pin Simon, Alexandra Craciun, Simona Rednic

Correspondence should be addressed to: Paulina Vele

Abstract:

Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC). Methods: Thirty-six patients with CC and thirty-seven controls were consecutively enrolled in this pilot case-control, cross-sectional study. The following parameters were assessed: serum levels of OC, OPG and β-CTx by enzyme-linked immunosorbent assay (ELISA); hip and spine BMD by dual-energy X-ray absorptiometry and AAC score by lateral radiography. Results: Patients with CC had higher levels of serum bone turnover markers and AAC score than the control group: OC [6.5 (3.5-9.9) vs 4.5 (2.6-7.2) ng/ml; p=0.05], OPG [(7.7 (6.2-9.4) vs 6.5 (5.5-8.12) pmol/ml; p=0.02], β-CTx [6078 (5870-6171) vs 5851 (5465-6109) pg/ml; p=0.02] and AAC score (3.6±6.2 vs 0.5±2; p=0.006). Conversely, even if statistical significance was not reached, hip and spine BMD was lower in patients with CC. Additionally, we found a positive correlation between OPG and AAC, but also between OPG and osteoporosis in patients with CC. Conclusion: Patients with CC are characterized by higher circulating OC, OPG and β-CTx. The presence of AAC was more common in patients with CC, being only associated with serum OPG.

Keywords: chondrocalcinosis, osteocalcin, osteoprotegerin, beta cross laps, abdominal aortic calcifications

Received: 25.11.2019
Accepted: 19.2.2020
Published: 5.3.2020

 
  PDF Download full text PDF
(417 KB)
     
 
How to cite
Vele P, Silaghi CN, Damian LO, Simon SP, Craciun A, Rednic S. Bone status and aortic calcifications in chondrocalcinosis patients. Rev Romana Med Lab. 2020;28(2):195-204. DOI:10.2478/rrlm-2020-0019