RRML - New Para-Clinical Investigations in the Celiac Disease
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Dr. Adrian Man
   
 
Nr. 18(2)/2010
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New Para-Clinical Investigations in the Celiac Disease

Gabriel Samaşca, Mihaela Iancu, Angela Butnariu, Mariana Andreica, Doru Dejica


Abstract:

Introduction: Deficiencies of native antigliadin antibodies tests lead to the decrease of interest but, at the same time, to more serious studies of molecular biology in connection with this test. The discovery of specific B lymphocytes epitopes on certain deamidated gliadin molecules has led to a new serological test, the deamidated antigliadin antibodies. We aimed to evaluate these antibodies and to determine the possible connections with immunoglobulin A deficit in the child’s celiac disease. Method: During 2008 we carried out an observational analytical study that determined both IgG and IgA immunoglobulin isotypes of the deamidated antigliadin antibodies in a group of 102 children from Cluj area, of which 31 children had celiac disease, under gluten-free diet, and 71 children, without diagnosis but with clinical signs of celiac disease. Results: After evaluating the qualities of the deamidated antigliadin antibodies, we obtained a sensitivity of 80% (95% CI 28-99) and a specificity of 88.4% (95% CI 74-96) for the 0-3 years age group (p=0,007). In older children, the test’s sensitivity decreased but the specificity remained at close values, as the children got older. At the same time, in 4% of the children we observed a good correlation with the A immunoglobulin deficit. Conclusions: Assessment of the IgA+IgG deamidated antigliadin antibodies represents a useful test in the celiac disease screening, mainly for the 0-3 years age group. This test also helps detecting the A immunoglobulin deficit.

Keywords: Celiac disease,deamidated antigliadin antibodies,immunoglobulin A deficit

 
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How to cite
Samaşca G, Iancu M, Butnariu A, Andreica M, Dejica D. New Para-Clinical Investigations in the Celiac Disease. Rev Romana Med Lab. 2010;18(2):43-51