 |
|
- Main page
- News
- RJLabM Credits
- Archive
- Instructions for authors
- Online applications
- Editorial
- About us
-
Links
- Committee on Publication Ethics (COPE)
- International Committee of Medical Journal Editors
- Acta Marisiensis Seria Medica
- Bacteriologia, Virusologia, Parazitologia, Epidemiologia
- Biochemia Medica
- Clinical Chemistry and Laboratory Medicine
- Clinical Chemistry
- Clinica Chimica Acta
- Documenta Haematologica
- Romanian Journal of Morphology and Embryology
- Biostatistics and web search strategies (Romanian)
- How to spot a statistical problem
- Statistical Analyses and Methods in the Published Literature
ISSN online: 2284-5623
ISSN-L: 1841-6624
Rejection rate (2020): 75%
Journal Metrics
Impact Factor 0.5 Five Year Impact Factor 0.5 JCI 0.12
Log in
Concept, Design & Programming
Dr. Adrian Man
Research article Cynomorium Songaricum may protect against spermatogenic damage caused by cyclophosphamide in SD rats Xiaoxiao Han, Rongsheng Zhou, Wei Zheng, Xitao Wang, Shuyan Mao, Zhenbei Li, Lin Hao, Zhenduo Shi, Bo Chen, Zhiguo Zhang, Yijuan Cao, Dianjun Yu, Kun Pang, Conghui Han
Correspondence should be addressed to: Kun Pang , Conghui Han
Abstract: Aim: The aim of the study is to investigate the effect of Cynomorium songaricum (CS) on the damage caused by cyclophosphamide (CP) in SD rats. Methods: Rats with CP-induced oligoasthenospermia were treated with different concentration of CS. Testicle weight, epididymal sperm count (ESC), sperm motility, and serum testosterone were analyzed, and expression levels of Thy1, Oct4, PLZF, C-kit, and GDNF were detected in testis tissues. Transmission electron microscopy (TEM) was performed to observe the effect of CS on the spermatogenic damage by CP. Results: Compared with the CP group, there were significant differences in testicle weight, ESC, and sperm motility (p<0.05) observed in all concentrations of CS and CP+VitE groups (p<0.05). There were no significant differences in serum testosterone among the 6 groups (p>0.05). The qPCR results revealed a significant difference in Thy1, Oct4, PLZF and GDNF expression between the CP group and CS group (p <0.05), but there was no significant difference in C-kit between the two groups (p> 0.05). The damage of CP was cured by CS observed under TEM. Conclusion: CS can increase sperm counts in the epididymis and improve sperm motility and has a therapeutic effect on the spermatogenic damage caused by CP in SD rats. Keywords: Cynomorium Songaricum, spermatogenic damage, cyclophosphamide, epididymal sperm count, sperm motility
Received: 19.12.2018 |
|||||
|
Download full text PDF (5288 KB) |
||||
|
Han X, Zhou R, Zheng W, Wang X, Mao S, Li Z, et al. Cynomorium Songaricum may protect against spermatogenic damage caused by cyclophosphamide in SD rats. Rev Romana Med Lab. 2019;27(3):291-303. DOI:10.2478/rrlm-2019-0031
|
|||||