RRML - Peculiar hyper-IgM syndrome. Case report

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.493
Five Year Impact Factor 0.531
SNIP 0.373
JCI 0.17

Advanced search

Top 10 downloaded articles
- March 2023 -
Making the most out of profici... 22
Romanian Review of Laboratory ... 11
The Role of procollagen type 1... 11
Vitamin K and bone metabolism... 9
Endothelial progenitor cell (E... 8
Ferritin and procalcitonin in ... 8
Management of a case of Castle... 8
Non-invasive markers of fibros... 7
Insulin resistance associated ... 7
Persistent blood eosinophilia ... 7

Log in

Concept, Design & Programming
Dr. Adrian Man

Nr. 23(3)/2015 DOI:10.1515/rrlm-2015-0027

Peculiar hyper-IgM syndrome. Case report

Sorin Ioan Iurian, Laszlo Marodi, Capucine Picard


We report a male infant diagnosed at the age of 10 months with hyper-IgM syndrome (HIGM) in context of severe infections caused by Streptococcus pneumoniae, Staphylococcus aureus and Candida albicans. In patient’s outcome, in spite of immunoglobulin therapy, he continues presenting bilateral suppurative otitis media due to both Candida and penicillin-resistant pneumococcus and forearm abscess caused by Staphylococcus aureus. The infant developed bilateral cataracts, chronic hepatitis and comminuted fracture secondary to bone demineralization. The patient didn’t develop opportunistic infections as compare to CD40 Ligand deficiency patients. In contrast with the majority of HIGM cases, the infant necessity for immunoglobulin substitution was very limited. As a particularity of immunological phenotype, the patient IgM value progressively increased at a high level.

Keywords: hyper-IgM syndrome, severe infections, recurrent infections, bone disease

Received: 2.3.2015
Accepted: 26.7.2015
Published: 8.9.2015

  PDF Download full text PDF
(315 KB)
How to cite
Iurian SI, Marodi L, Picard C. Peculiar hyper-IgM syndrome. Case report. Rev Romana Med Lab. 2015;23(3):341-5. DOI:10.1515/rrlm-2015-0027