RRML - Changes in C-reactive protein, erythrocyte sedimentation rate, human leukocyte antigen-B27, and immunoglobulins A, G, M in patients with ankylosing spondylitis
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- May 2024 -
 
A comprehensive review of Prof... 30
Romanian Review of Laboratory ... 17
The role of nitro oxidative fa... 16
Effect of Systemic Inflammator... 16
Diagnostic value of stress myo... 15
Evaluation of routine laborato... 14
Correlations of expressions of... 13
Monitoring the sensitivity of ... 12
Evaluation of cytotoxicity and... 11
Recomandarea comună EFLM-COLA... 10

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 31(2)/2023 DOI:10.2478/rrlm-2023-0012
XML
TXT

Research article

Changes in C-reactive protein, erythrocyte sedimentation rate, human leukocyte antigen-B27, and immunoglobulins A, G, M in patients with ankylosing spondylitis

Lixiu Zhu, Sujuan Zhou, Ye Lin, Zhen Ye, Yirong Tang, Renli Chen

Correspondence should be addressed to: Renli Chen

Abstract:

Background: To explore the changes in C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), human leukocyte antigen-B27 (HLA-B27), and immunoglobulin (Ig) (IgA, IgG, and IgM) in patients suffering from ankylosing spondylitis (AS). Methods: A total of 232 patients with axial spondyloarthritis admitted from January 2020 to December 2021 were selected, among whom 132 were AS patients (AS group) and 100 were non-AS cases (non-AS group). Meanwhile, 100 healthy subjects undergoing physical examination were included as a control group. Peripheral blood was collected to detect the levels of CRP, ESR, HLA-B27, IgA, IgG, and IgM. Results: The positive rates and levels of CRP, ESR, HLA-B27, IgG, and IgM in non-AS and AS groups were significantly higher, and the IgA level of the AS group was higher than those of the control group (P<0.05). The AS group had significantly higher positive rates and levels of CRP, ESR, HLA-B27, and IgA than those of the non-AS group (P<0.05). The levels of HLA-B27, ESR and CRP had positive correlations with those of IgA, IgG and IgM (P<0.05). The area under the curve (AUC) of HLA-B27 with a cut-off value of 53.18 U/mL for the diagnosis of AS was 0.879. AUC of ESR with a cut-off value of 23.83 mm/h for the diagnosis of AS was 0.811. AUC of CRP with a cut-off value of 14.35 mg/L for the diagnosis of AS was 0.745. With the cut-off values of 2.75 g/L, respectively, AUC of IgA for the diagnosis of AS were 0.668. AUC of the combined diagnosis was 0.929 (P<0.05). Conclusions: AS patients have abnormally elevated levels of HLA-B27, ESR, CRP, and IgA, and the combined detection has a higher diagnostic value. The abnormal increase in IgA, IgG, and IgM is positively correlated with rheumatic inflammation marker HLA-B27, CRP, and ESR.

Keywords: ankylosing spondylitis, C-reactive protein, erythrocyte sedimentation rate, human leukocyte antigen-B27, immunoglobulin

Received: 12.12.2022
Accepted: 30.3.2023
Published: 13.4.2023

 
  PDF Download full text PDF
(971 KB)
     
 
How to cite
Zhu L, Zhou S, Lin Y, Ye Z, Tang Y, Chen R. Changes in C-reactive protein, erythrocyte sedimentation rate, human leukocyte antigen-B27, and immunoglobulins A, G, M in patients with ankylosing spondylitis. Rev Romana Med Lab. 2023;31(2):113-8. DOI:10.2478/rrlm-2023-0012