RRML - The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

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ISSN online: 2284-5623

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Nr. 30(1)/2022 DOI:10.2478/rrlm-2021-0036

Research article

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Seda Avnioglu, Meltem Güngör, Ergul Kurutas, Unal Ozturk, Ilter Demirhan, Sevgi Bakaris, Halil A. Velioglu, Seyda Cankaya, Burak Yulug

Correspondence should be addressed to: Seda Avnioglu

Abstract:

Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.

Keywords: resveratrol, ischemia/reperfusion injury, antioxidant, oxidative stress, heart

Received: 25.5.2021
Accepted: 5.10.2021
Published: 20.10.2021

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Avnioglu S, Güngör M, Kurutas E, Ozturk U, Demirhan I, Bakaris S, et al. The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model. Rev Romana Med Lab. 2022;30(1):9-18. DOI:10.2478/rrlm-2021-0036