RRML - Predictors associated with increased troponin in acute decompensated and chronic heart failure patients

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Dr. Adrian Man

Nr. 29(2)/2021 DOI:10.2478/rrlm-2021-0015

Research article

Predictors associated with increased troponin in acute decompensated and chronic heart failure patients

Anamaria Draghici, Catalin Adrian Buzea, Caterina Delcea, Ancuta Vijan, Gheorghe Andrei Dan

Correspondence should be addressed to: Catalin Adrian Buzea


Background: Myocardial injury (INJ) expressed by elevated high-sensitivity troponin (hs-Tn) is common in heart failure (HF), due to cardiovascular and non-cardiac conditions. The mechanisms of INJ in acute decompensated HF (ADHF) versus chronic HF (CHF) are still debated. This study’s purpose was to evaluate the determinants of elevated hs-TnT in ADHF and CHF. Methods: We retrospectively analyzed consecutive HF patients with hs-TnT measured on admission, hospitalized in a tertiary-care hospital. Rehospitalizations, acute coronary syndromes, embolisms, infections, autoimmunity and malignancy were excluded. Cut-off point for hs-TnT was 14 ng/L. Results: Our study included 488 HF patients, 56.55% with ADHF. Mean age was 72.52±10.09 years. 53.89% were females. 67.75% ADHF and 45.75% CHF patients had elevated hs-TnT. Median hs-TnT was higher in ADHF versus CHF (21.05[IQR 12.74-33.81] vs 13.20[IQR 7.93-23.25], p<0.0001). In multivariable analysis in ADHF and CHF, log10NT-proBNP (HR=5.30, 95%CI 2.71–10.38, p<0.001, respectively HR=5.49, 95%CI 1.71–17.57, p=0.004) and eGFR (HR=0.72, 95%CI 0.62–0.85, p<0.001, respectively HR=0.71, 95%CI 0.55–0.93, p=0.014) were independent predictors for increased hs-TnT. Independent factors associated with elevated hs-TnT in ADHF were male sex (HR=2.52, 95%CI 1.31-4.87, p=0.006) and chronic pulmonary obstructive disease (COPD) (HR=10.57, 95%CI 1.26-88.40, p=0.029), while in CHF were age (HR=2.68, 95%CI 1.42-5.07, p=0.002) and previous stroke (HR=5.35, 95%CI 0.98-29.20, p=0.053). Conclusion: HF severity, expressed by NT-proBNP levels, and kidney disease progression, expressed by eGFR, were independent predictors associated with increased hs-TnT in both ADHF and CHF. Specific independent predictors were also indentified in ADHF (male sex, COPD) and CHF (age, history of stroke).

Keywords: predictors, high sensitive troponin, acute decompensated heart failure, chronic heart failure

Received: 13.2.2021
Accepted: 7.3.2021
Published: 17.3.2021

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How to cite
Draghici A, Buzea CA, Delcea C, Vijan A, Dan GA. Predictors associated with increased troponin in acute decompensated and chronic heart failure patients. Rev Romana Med Lab. 2021;29(2):153-64. DOI:10.2478/rrlm-2021-0015