RRML - Ischemia modified albumin in experimental ovarian torsion with and without controlled reperfusion

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Nr. 27(1)/2019 DOI:10.2478/rrlm-2019-0008

Research article

Ischemia modified albumin in experimental ovarian torsion with and without controlled reperfusion

Cornelia Lazăr, Marin Vozian, Valeriana Pantea, Ana Mișina, Olga Tagadiuc

Correspondence should be addressed to: Cornelia Lazăr

Abstract:

Purpose: Ovarian torsion, being a gynecological emergency, requires to be rapidly diagnosed and treated with minimal consequences on ovarian function after the removal of torsion. As ischemia modified albumin (IMA) is considered a good biomarker in diverse ischemic diseases, the aim of our study was to determine the effect of different ovarian torsion/detorsion models on serum and ovarian homogenates levels of IMA in an experimental study. Methods: IMA was measured in the serum and ovarian homogenates of 7 groups of female rats (10 animals in each group): 1 - control (no intervention); 2 - sham (only laparotomy); 3 - ischemia group: 3 hours ovarian torsion (OT); 4 - 3 hours OT (ischemia), 1 hour simple reperfusion; 5 - 3 hours ischemia, 1 hour controlled reperfusion that was assured during the first two minutes by opening and closing the clips on the ovarian pedicles in 10 seconds intervals, followed by simple reperfusion; 6 - 3 hours ischemia, 24 hours simple reperfusion; 7 - 3 hours OT, 24 hours controlled reperfusion. The results were analyzed by Welch’s ANOVA and Spearman correlation. Results: Ischemia increases the IMA in both serum and ovarian homogenates compared to control and sham groups. The controlled reperfusion groups had a statistically significant lower IMA in serum compared to simple reperfusion groups. IMA was found to be higher in the ovarian homogenates of simple reperfusion compared to controlled reperfusion groups. Conclusion: Our results suggest that controlled reperfusion prevent the processes that increase the IMA in ovarian torsion.

Keywords: ovarian torsion, ischemia modified albumin

Received: 8.11.2018
Accepted: 28.12.2018
Published: 31.12.2018

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Lazăr C, Vozian M, Pantea V, Mișina A, Tagadiuc O. Ischemia modified albumin in experimental ovarian torsion with and without controlled reperfusion. Rev Romana Med Lab. 2019;27(1):43-50. DOI:10.2478/rrlm-2019-0008