RRML - Intestinal type in situ adenocarcinoma of the cervix as a precursor of cervical signet ring cell adenocarcinoma

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Nr. 20(3)/2012

Intestinal type in situ adenocarcinoma of the cervix as a precursor of cervical signet ring cell adenocarcinoma

Gavrilas Muresan, Kinga E. Szabo, Cristina Marian, Monica Boros, Nicolae Costin, Simona Stolnicu

Abstract:

In the cervix, signet ring cell adenocarcinoma of the cervix is usually of metastatic origin. Only in rare cases it can develop as a primary, with only 12 cases reported to date. Characteristically, tumor cells with eccentric nuclei and pale basophilic cytoplasm are present in nests or clusters. We present here the case of a 41 year old patient diagnosed three years before of a mixed high grade cervical intraepithelial neoplasia (CIN III) and intestinal adenocarcinoma in situ that was excised by a cone biopsy. Cytologic follow-up for a period of 3 years revealed no abnormal cells. She eventually presented with a polypoid mass protruding through the external cervical os. The biopsy showed a solid proliferation of characteristic signet ring cells with immunohistochemical results thet further supported a cervical immunophenotype. This is the first documented case demonstrating a precursor lesion of intestinal type adenocarcinoma for a primary infiltrating signet ring carcinoma of the cervix. Intestinal differentiation is almost invariably associated with invasive features.

Keywords: intestinal in situ adenocarcinoma,signet ring cell adenocarcinoma,cervix

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Muresan G, Szabo KE, Marian C, Boros M, Costin N, Stolnicu S. Intestinal type in situ adenocarcinoma of the cervix as a precursor of cervical signet ring cell adenocarcinoma. Rev Romana Med Lab. 2012;20(3):273-8