RRML - Association of betaine-homocysteine S-methyltransferase gene G742A SNP and male infertility

Main page
News
RJLabM Credits
Archive
- Current issue
- Ahead of print
- List of published issues
- 2024
  - Nr.3/2024
  - Nr.2/2024
  - Nr.1/2024
- 2023
  - Nr.4/2023
  - Nr.3/2023
  - Nr.2/2023
  - Nr.1/2023
  - Supplement 1/2023
- 2022
  - Nr.4/2022
  - Nr.3/2022
  - Nr.2/2022
  - Nr.1/2022
  - Supplement 1/2022
- 2021
  - Nr.4/2021
  - Nr.3/2021
  - Nr.2/2021
  - Nr.1/2021
- 2020
  - Nr.4/2020
  - Nr.3/2020
  - Nr.2/2020
  - Nr.1/2020
  - Supplement 1/2020
- 2019
  - Nr.4/2019
  - Nr.3/2019
  - Nr.2/2019
  - Nr.1/2019
  - Supplement 1/2019
- 2018
  - Nr.4/2018
  - Nr.3/2018
  - Nr.2/2018
  - Nr.1/2018
  - Supplement 1/2018
  - Supplement 2/2018
  - Supplement 3/2018
- 2017
  - Nr.4/2017
  - Nr.3/2017
  - Nr.2/2017
  - Nr.1/2017
  - Supplement 1/2017
- 2016
  - Nr.4/2016
  - Nr.3/2016
  - Nr.2/2016
  - Nr.1/2016
  - Supplement 1/2016
- 2015
  - Nr.4/2015
  - Nr.3/2015
  - Nr.2/2015
  - Nr.1/2015
  - Supplement 1/2015
- 2014
  - Nr.4/2014
  - Nr.3/2014
  - Nr.2/2014
  - Nr.1/2014
  - Supplement 1/2014
- 2013
  - Nr.4/2013
  - Nr.3/2013
  - Nr.2/2013
  - Nr.1/2013
  - Supplement 1/2013
- 2012
  - Nr.4/2012
  - Nr.3/2012
  - Nr.2/2012
  - Nr.1/2012
  - Supplement 1/2012
- 2011
  - Nr.4/2011
  - Nr.3/2011
  - Nr.2/2011
  - Nr.1/2011
  - Supplement 1/2011
- 2010
  - Nr.4/2010
  - Nr.3/2010
  - Nr.2/2010
  - Nr.1/2010
  - Supplement 1/2010
- 2009
  - Nr.4/2009
  - Nr.3/2009
  - Nr.2/2009
  - Nr.1/2009
  - Supplement 1/2009
- 2008
  - Nr.4/2008
  - Nr.3/2008
  - Nr.2/2008
  - Nr.1/2008
  - Supplement 1/2008
- 2007
  - Nr.4/2007
  - Nr.3/2007
  - Nr.2/2007
  - Nr.1/2007
- 2006
  - Nr.4/2006
  - Nr.3/2006
  - Nr.2/2006
  - Nr.1/2006
- 2005
  - Nr.1/2005
Instructions for authors
Online applications
- Send an article
- Online payments
Editorial
About us
Links

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Top 10 downloaded articles - September 2024 -

Romanian Review of Laboratory ...	11
Small patients, big challenges...	8
Monocyte to high-density lipop...	6
A comprehensive review of Prof...	6
The role of nitro oxidative fa...	6
Beyond PSA: a multi-modal pilo...	6
Function of the S1P pathway in...	5
Challenges in prophylactic the...	5
Correlations of high miRNA exp...	5
Implementing essential require...	5

Concept, Design & Programming
Dr. Adrian Man

Nr. 20(1)/2012

Association of betaine-homocysteine S-methyltransferase gene G742A SNP and male infertility

Radu A. Popp, Marius F. Farcaş, Adrian P. Trifa, Tania O. Crişan, Mariela S. Militaru, Ioan V. Pop

Abstract:

The folate metabolic pathway is a complex biochemical chain of reactions essential for cellular function. Within this pathway BHMT (betaine-homocysteine S-methyltransferase) catalyzes the conversion of homocysteine to methionine. The BHMT G742A SNP (single nucleotide polymorphism) is suspected to alter the enzyme’s normal activity, hence increasing homocysteine and reducing folate plasma levels. We analyzed the distribution of this single nucleotide polymorphism in the BHMT gene in a case group of 66 infertile Romanian patients with idiopathic azoospermia or severe oligozoospermia and a control group of 67 fertile Romanian men, to explore the possible association of the G742A polymorphism and male infertility. Using the polymerase chain reaction – restriction fragment length polymorphism technique (PCR-RFLP), the allele and genotype distribution of SNP G742A in the BHMT gene was investigated in both patients and controls. The allelic frequencies of the variant A allele were significantly higher in the patients group compared to the controls. Our findings suggest that the BHMT G742A SNP is a genetic risk factor for idiopathic male infertility in our Romanian population group.

Keywords: infertility,homocysteine,folate,azoospermia

Download full text PDF
(97 KB)

Popp RA, Farcaş MF, Trifa AP, Crişan TO, Militaru MS, Pop IV. Association of betaine-homocysteine S-methyltransferase gene G742A SNP and male infertility. Rev Romana Med Lab. 2012;20(1):57-62