RRML - Clinical, laboratory and molecular features in essential thrombocythemia
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- July 2024 -
 
A comprehensive review of Prof... 13
Romanian Review of Laboratory ... 7
Evaluation of routine laborato... 5
Monocyte to high-density lipop... 4
The role of nitro oxidative fa... 4
Diagnostic value of stress myo... 4
The frequency of EGFR gene mut... 4
Assessment of ocrelizumab impa... 4
Correlations of high miRNA exp... 4
The usefulness of IS6110 neste... 3

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 19(2)/2011
XML
TXT

Clinical, laboratory and molecular features in essential thrombocythemia

Laura G. Urian, Adrian P. Trifa, Ljubomir Petrov, Mariana Paţiu


Abstract:

Essential thrombocyhtemia is a BCR-ABL negative myeloproliferative disorder (MPD) distinct from polycytemia vera and idiopathic myelofibrosis and characterized by persistent thrombocytosis, excessive proliferation of megakariocytes in the bone marrow, normal erythrocytic mass and the absence of prominent bone marrow fibrosis. In the last few years new information on pathogenesis of myeloproliferative disorders became available: the discovery of an acquired recurrent molecular abnormality in the 14th exon of the JAK2V617F gene resulting in a substitution of valine for phenylalanine at position 617 in the JAK2 protein (V617). We analyzed the recently identified JAK2V617F mutational status, the relevance of mutated allele burden for clinical presentation, thrombosis and hemorrhagic complications.

Keywords: essential thrombocytemia,mutation JAK2 V617F,thrombosis and hemorrhagic complications

 
  PDF Download full text PDF
(226 KB)
     
 
How to cite
Urian LG, Trifa AP, Petrov L, Paţiu M. Clinical, laboratory and molecular features in essential thrombocythemia. Rev Romana Med Lab. 2011;19(2):129-38