RRML - Angiotensin-converting enzyme gene polymorphisms in pulmonary arterial hypertension in children
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- July 2024 -
 
A comprehensive review of Prof... 13
Romanian Review of Laboratory ... 7
Evaluation of routine laborato... 5
Monocyte to high-density lipop... 4
The role of nitro oxidative fa... 4
Diagnostic value of stress myo... 4
The frequency of EGFR gene mut... 4
Assessment of ocrelizumab impa... 4
Correlations of high miRNA exp... 4
The usefulness of IS6110 neste... 3

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 18(4)/2010
XML
TXT

Angiotensin-converting enzyme gene polymorphisms in pulmonary arterial hypertension in children

Rodica Togănel, Claudia Bănescu, Carmen Duicu, Carmen Şuteu, Iolanda Muntean, Amalia Făgărăşan, Liliana Gozar, Sorina Pasc


Abstract:

Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary arterial hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary arterial hypertension in children. Methods and Results. We performed a case-control study involving 29 patients with pulmonary arterial hypertension and 26 healthy controls. Genomic DNA extracted from peripheral blood was amplified using the polymerase chain reaction to detect the polymorphic marker. In patients, ACE genotype distribution of DD, ID, and II was 34.5%, 58.6%, and 6.9%, respectively, whereas in controls it was 11.5%, 69.3%, and 19.2%, respectively. Conclusion. The ACE DD genotype is significantly increased in patients with pulmonary hypertension compared with normal controls, suggesting that certain individuals may be genetically predisposed to developing pulmonary hypertension.

Keywords: pulmonary hypertension,gene polymorphisms,angiotensin converting enzyme.

 
  PDF Download full text PDF
(112 KB)
     
 
How to cite
Togănel R, Bănescu C, Duicu C, Şuteu C, Muntean I, Făgărăşan A, et al. Angiotensin-converting enzyme gene polymorphisms in pulmonary arterial hypertension in children. Rev Romana Med Lab. 2010;18(4):31-6