RRML - Multiparametric approach of prognostic factors in acute myeloid leukemia

RRML - Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study

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Nr. 14(1)/2009

Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study

Anca Bacârea, Mariana Paţiu, Andrei Cucuianu, Delia Dima, Vladimir Bacârea, Bogdana Dorcioman, Minodora Dobreanu, Galafteon Oltean

Abstract:

Acute myeloid leukemias (AML) are a group of malignant hematologic disorders with varying clinical, morphologic, immunologic and molecular characteristics. Prognostic factors evaluation remains an important subject of study in order to improve the outcome of patients with AML, a disease with poor prognostic by itself. Establishing prognosis at the time of diagnosis is expected in order to stratify treatment. The aim of this study is to evaluate some prognostic factors in AML: age, leukocyte count, platelet count, FAB (French-American-British Cooperative Group) subtype, LDH serum level, immunophenotype at diagnosis. We included 59 patients with primary or secondary AML at the time of diagnostic, with complete investigation at the Hematology Department of Medical Clinic I in Tg-Mureş and at the Hematology Department of “Ion Chiricuţă” Cancer Institute Cluj-Napoca. Our results indicate that leukocyte count over 100000/µL, LDH serum activities over 1000 U/L and C34+CD56+ association are significant prognostic factors in AML at the time of diagnostic. FAB subtypes M0, M1, M4 significantly influenced complete remission. Due to the low number of cases prognostic evaluation of cytogenetics and molecular findings is not possible. These results represent an intermediary evaluation of patients, because the study is still underway.

Keywords: AML,prognostic,immunophenotyping

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Bacârea A, Paţiu M, Cucuianu A, Dima D, Bacârea V, Dorcioman B, et al. Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study. Rev Romana Med Lab. 2009;14(1):41-8