RRML - Resistance to antiretroviral therapy in HIV infected patients
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- February 2024 -
 
Anti-thyroid peroxidase (TPO) ... 18
Romanian Review of Laboratory ... 17
Recomandarea comună EFLM-COLA... 13
Approaching Risk Management in... 12
Identification of shared hub g... 12
Challenges in prophylactic the... 12
Monocyte to high-density lipop... 9
Atellica CH 930 chemistry anal... 8
Setting up an own laboratory p... 7
Understanding the key differen... 7

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 6(1)/2007
XML
TXT

Resistance to antiretroviral therapy in HIV infected patients

Márta Andrea Fodor, Minodora Dobreanu, Rodica Pascu, Monica Sabău


Abstract:

Purpose: to determine the frequency of resistance mutations in patients treated in Mures Regional Center of Monitoring of HIV Infection. Material and methods: We included in our study 24 patients with HIV infection. The resistance testing was performed by viral genotyping in the Laboratory of Molecular Diagnosis of Infectious Diseases Institute “Prof. Matei Balş”, Bucharest. We also followed the age, the gender, the provenience of patients and the number modifications in CD4 and CD8 lymphocytes and viral load before and after testing. Results: we observed an increase in number of CD4, CD8 lymphocytes, in the CD4/CD8 ratio and a decrease in viral load. The most frequent mutations of resistance were: in the RT gene: M148V, M41L, T215Y, D67N, K70R, Y181C, K103N, and in the PR gene: L10I, I54V, L10V, K20R, M36I, V82A. We observed a great number of resistance/ intermediate sensibility for the following drugs: IDV, RTV, DLV, EFV, NVP, AZT, ABC, NFV, ddC, SQV. Conclusions: repeated, periodical testing of antiretroviral resistance in the ARV treated pactients is necessary for optimal treatment of these patients.

 
  PDF Download full text PDF
(742 KB)
     
 
How to cite
Fodor MA, Dobreanu M, Pascu R, Sabău M. Resistance to antiretroviral therapy in HIV infected patients. Rev Romana Med Lab. 2007;6(1):15-24