RRML - Genetic risk factors for thrombosis and complications during pregnancy

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- April 2024 -
A comprehensive review of Prof... 24
Recomandarea comună EFLM-COLA... 13
Monocyte to high-density lipop... 9
Anti-thyroid peroxidase (TPO) ... 9
Understanding the key differen... 7
Understanding the pathogenesis... 7
Function of the S1P pathway in... 6
Predictive value of expression... 5
The importance of tumor marker... 4
Romanian Review of Laboratory ... 4

Log in

Concept, Design & Programming
Dr. Adrian Man

Nr. 1(1)/2005

Genetic risk factors for thrombosis and complications during pregnancy

Domniţa Crişan, Ruxandra Alecsandrescu


Thrombembolism is a multicausal disease in which both acquired and genetic risk factors and also their interaction play a role. Inherited thrombophilia is now demonstrated to be a multigenic disease; the most common genetic risk factors are factor V Leiden and the prothrombin mutations. Prior to the discovery of these mutations, three less common genetic risk factors had been reported in thrombophilia families: antithrombin, protein C and protein S deficiencies. Dysfibrinogenemias are the least common causes of inherited thrombophilia. The risk of venous thrombosis associated with pregnancy is further increased in women with inherited thrombophilia, resulting in higher incidence of thromboembolic complications during pregnancy and puerperium and also higher incidence of fetal loss, fetal growth retardation, preeclampsia and abruptio placentae. For management and prevention of thrombotic complication of pregnancy, testing for the genetic risk fac-tors have became indispensable.

  PDF Download full text PDF
(114 KB)
How to cite
Crişan D, Alecsandrescu R. Genetic risk factors for thrombosis and complications during pregnancy. Rev Romana Med Lab. 2005;1(1):48-51