RRML - Genotype comparison of Candida albicans isolates from different clinical samples

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ISSN online: 2284-5623

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Nr. 27(3)/2019 DOI:10.2478/rrlm-2019-0027

Research article

Genotype comparison of Candida albicans isolates from different clinical samples

Andra-Cristina Bostănaru, Irina Roșca, Bogdan Minea, Valentin Năstasă, Liliana Foia, Iosif Marincu, Mihai Mares, Ovidiu-Alexandru Mederle

Correspondence should be addressed to: Mihai Mares

Abstract:

Background: Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on the correlation between the infection site and the genotypes of Candida albicans strains isolated from Romanian patients. Methods: A total number of 301 isolates from different clinical sites were investigated in terms of genotype determination. Results: The isolates were clustered in three groups according to their genotype: 55.81% showed genotype A, 14.62% genotype B, and 29.57% genotype C. Conclusions: No significant correlation was found between the genotype and the infection site, but a significant correlation was found between genotype C and isolates from HIV patients proving that C. albicans pathogenicity probably relies on factors related to the host.

Keywords: C. albicans, clinical source, genotype C, HIV-patients, Romania

Received: 22.1.2019
Accepted: 15.4.2019
Published: 18.6.2019

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Bostănaru AC, Roșca I, Minea B, Năstasă V, Foia L, Marincu I, et al. Genotype comparison of Candida albicans isolates from different clinical samples. Rev Romana Med Lab. 2019;27(3):327-32. DOI:10.2478/rrlm-2019-0027