RRML - Laboratory investigation of the organ non-specific autoimmune diseases

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ISSN online: 2284-5623

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Dr. Adrian Man

Nr. 14(1)/2009

Laboratory investigation of the organ non-specific autoimmune diseases

Anca Cristea

Abstract:

Autoantibodies have been used extensively as a useful biomarker in many autoimmune diseases. The detection of circulating autoantibodies to nuclear antigens in systemic conective tissue diseases or to some of neutrophil citoplasmatic antigens in vasculitis is an important tool in the diagnosis. Many techniques have been developed to detect these autoantibodies, but the indirect immmunoflurescence is considered to be the standard clinical test to screen sera before other techniques, like ELISA, to define antibody specificity. In the last years multiplexed technologies were developed that have a a high specificity and the capacity of measuring a high number of autoantibodies from a single sample. Measurement of autoantibodies is not a replacement for clinical diagnosis. This review focuses on tehniques used to asses the autoantibodies and to evaluation of their clinical significance in some disease subsets.

Keywords: antinuclear autoantibodies,ANCA,indirect immunoflurescence

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Cristea A. Laboratory investigation of the organ non-specific autoimmune diseases. Rev Romana Med Lab. 2009;14(1):63-77