RRML - Biochemical risk factors associated with refractory epilepsy: alpha synuclein and adenosine deaminase

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ISSN online: 2284-5623

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Nr. 32(3)/2024 DOI:10.2478/rrlm-2024-0021

Research article

Biochemical risk factors associated with refractory epilepsy: alpha synuclein and adenosine deaminase

Nurdan Şener, Didem Barlak Keti, Ayten Güleç, Mehmet Canpolat, Hüseyin Per, Hakan Gümüş, Sabahattin Muhtaroğlu

Correspondence should be addressed to: Didem Barlak Keti

Abstract:

Background: Epilepsy is a common chronic neurological disorder affecting all age groups. A significant portion of children with epilepsy develop drug-resistant seizures. These children are at risk of cognitive and behavioral comorbidities and death. Some clinical features provide important information about the prognosis of epilepsy. However, currently, there is no objective biochemical indicator associated with refractory epilepsy. This study aimed to determine whether serum alpha-synuclein (αS), p-glycoprotein (P-gp), and adenosine deaminase activity (ADA) were biochemical risk factors for refractory epilepsy. Methods: The cross-sectional study included patients diagnosed with refractory epilepsy (n=32), non-refractory epilepsy (n=35) and 20 healthy children under the age of 18 who applied to the Pediatric Neurology outpatient clinic. In the serum samples, αS and P-gp were analyzed by ELISA and ADA activity was analyzed by spectrophotometric method. ROC analysis was applied and the area under the curve (AUC) was calculated to define cut-off values in distinguishing refractory epilepsy patients from non-refractory epilepsy patients. Binary logistic regression analysis was performed to define risk factors associated with resistance in patients with epilepsy. Results: Children with epilepsy whose ADA activity and αS values were higher than the determined cut-off values had 10-fold and 5.3-fold increased risk of refractory epilepsy, respectively. Conclusions: αS and ADA activity can be used as biochemical risk factors for refractory epilepsy. However, these results need to be confirmed by prospective studies with many patients.

Keywords: adenosine deaminase, alpha-synuclein, p-glycoprotein, refractory epilepsy, risk factors

Received: 2.5.2024
Accepted: 4.7.2024
Published: 25.7.2024

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Şener N, Keti DB, Güleç A, Canpolat M, Per H, Gümüş H, et al. Biochemical risk factors associated with refractory epilepsy: alpha synuclein and adenosine deaminase. Rev Romana Med Lab. 2024;32(3):255-61. DOI:10.2478/rrlm-2024-0021