RRML - Improvement of total antioxidant status, a possible bioeffect of the ultrasound therapy

RRML - Improvement of total antioxidant status, a possible bioeffect of the ultrasound therapy - a pilot study

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Nr. 19(2)/2011

Improvement of total antioxidant status, a possible bioeffect of the ultrasound therapy - a pilot study

Rodica Ungur, Maria Dronca, Elena C. Crăciun, Răzvan L. Rusu, Mădălina Văleanu, Ioan Onac, Ileana M. Borda, Laszlo Irsay

Abstract:

The importance of the oxidative stress in the pathogenesis of osteoarthritis (OA) is well recognized at present. Nowadays, the ultrasound (US) therapy is successfully used to treat OA, but the precise mechanism of action is not yet completely understood. The present study monitored the effects of the US therapy over the clinical and functional parameters and the antioxidant/oxidant status, in patients with knee OA. A group of 12 patients diagnosed with knee OA were treated with US therapy (0.5 watt/cm2, for 5 minutes, during 10 sessions, 5 times/week). Before and after the US therapy the Womac score (WS), the Lequesne index (LI), and the total antioxidant status (TAS), the total oxidant status (TOS), superoxide dismutase (SOD), reduced/total glutathione and malonyldialdehyde (MDA) levels were measured. A statistically significant improvement (P < 0.05) was observed regarding both studied clinicaly parameters (WS, LI) and TAS. However, there were no significant differences between levels of TOS, SOD, reduced/total glutathione and MDA before and after US therapy. The increase of TAS could represent one of the possible mechanism through which the US therapy exerts its favorable effects in OA. Further studies will be required to investigate the biochemical nature of TAS increase.

Keywords: ultrasound therapy,arthrosis,antioxidant status

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Ungur R, Dronca M, Crăciun EC, Rusu RL, Văleanu M, Onac I, et al. Improvement of total antioxidant status, a possible bioeffect of the ultrasound therapy - a pilot study. Rev Romana Med Lab. 2011;19(2):177-83