RRML - Carcinosarcoma of the breast with massive osseous malignant component: a basal-like entity with myoepithelial differentiation

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Nr. 21(1)/2013 DOI:10.2478/rrlm-2013-0019

Carcinosarcoma of the breast with massive osseous malignant component: a basal-like entity with myoepithelial differentiation

Cristina Marian, Daniela Soanca, Kinga Szabo, Monica Boros, Simona Stolnicu

Abstract:

We present the case of a 77 year old patient with a primary breast carcinosarcoma composed mostly of an osteogenic sarcoma of fibroblastic type in which only immunohistochemical analysis disclosed the presence of a minor malignant epithelial component. The malignant mesenchymal component derives from dedifferentiation of myoepithelial cells since myoepithelial markers are positive. Also, like the majority of the other metaplastic carcinomas in the breast, carcinosarcoma is a basal type of tumor that will not respond to endocrine drugs or Her2/neu therapy.

Keywords: carcinosarcoma,osseous differentiation,basal-like,myoepithelial differentiation

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Marian C, Soanca D, Szabo K, Boros M, Stolnicu S. Carcinosarcoma of the breast with massive osseous malignant component: a basal-like entity with myoepithelial differentiation. Rev Romana Med Lab. 2013;21(1):67-73. DOI:10.2478/rrlm-2013-0019