RRML - Genetic risk factors for thrombosis and complications during pregnancy

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Nr. 1(1)/2005

Genetic risk factors for thrombosis and complications during pregnancy

Domniţa Crişan, Ruxandra Alecsandrescu

Abstract:

Thrombembolism is a multicausal disease in which both acquired and genetic risk factors and also their interaction play a role. Inherited thrombophilia is now demonstrated to be a multigenic disease; the most common genetic risk factors are factor V Leiden and the prothrombin mutations. Prior to the discovery of these mutations, three less common genetic risk factors had been reported in thrombophilia families: antithrombin, protein C and protein S deficiencies. Dysfibrinogenemias are the least common causes of inherited thrombophilia. The risk of venous thrombosis associated with pregnancy is further increased in women with inherited thrombophilia, resulting in higher incidence of thromboembolic complications during pregnancy and puerperium and also higher incidence of fetal loss, fetal growth retardation, preeclampsia and abruptio placentae. For management and prevention of thrombotic complication of pregnancy, testing for the genetic risk fac-tors have became indispensable.

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Crişan D, Alecsandrescu R. Genetic risk factors for thrombosis and complications during pregnancy. Rev Romana Med Lab. 2005;1(1):48-51