RRML - FGB -455 G>A and GP IIIa PIA1/A2 polymorphisms in a group of Romanian stroke patients

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Nr. 24(1)/2016 DOI:10.1515/rrlm-2016-0002

Short communication

FGB -455 G>A and GP IIIa PIA1/A2 polymorphisms in a group of Romanian stroke patients

Felicia Maria Petrișor, Andreea Cătană, Dragoș Horea Mărginean, Adrian Pavel Trifa, Radu Anghel Popp, Ioan Victor Pop

Correspondence should be addressed to: Felicia Maria Petrișor

Abstract:

Introduction: Being a multifactorial disease, stroke is one of a major causes of death and disability worldwide. Several genetic polymorphisms have been associated with stroke etiophatology and FGB -455 G>A and GP IIIa PIA1/A2 are among them. In the present study, we investigated the association between FGB -455 G>A and GP IIIa PIA1A2 polymorphisms and the risk of ischemic stroke in a group of Romanian stroke patients. Subjects and methods: This case-control study included 148 patients with ischemic stroke and 150 healthy age, sex and ethnically matched unrelated controls. FGB -455G>A and GP IIIa PIA1A2 genotyping was carried out using PCR-RFLP. The association of FGB -455G>A and GP IIIa PIA1A2 polymorphisms and cardiovascular risk factors with ischemic stroke was tested using logistic regression analysis. Results: Molecular analysis did not reveal an increased frequency of the FGB -455 G>A variant allele and GP IIIa PIA1/A2 variant allele in the study group compared to the control group (p = 0.140, OR = 0.750, 95% CI = 0.522- 1.077; p = 0.823, OR = 0.944, 95% CI = 0.558 - 1.599 respectively). Furthermore, after performing logistic regression analysis adjusted for the known risk factors, a positive association with stroke was found in smokers (p = 0.026, OR = 1.800, 95% CI = 1.071- 3.024) Conclusions: No association was found between FGB -455 G>A and GP IIIa PIA1/A2 polymorphisms and ischemic stroke in the studied population.

Keywords: ischemic stroke, fibrinogen, glycoprotein, polymorphism

Received: 11.8.2015
Accepted: 16.12.2015
Published: 23.1.2016

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Petrișor FM, Cătană A, Mărginean DH, Trifa AP, Popp RA, Pop IV. FGB -455 G>A and GP IIIa PIA1/A2 polymorphisms in a group of Romanian stroke patients. Rev Romana Med Lab. 2016;24(1):45-54. DOI:10.1515/rrlm-2016-0002