RRML - Comparative assessment of bone regeneration by histometry and a histological scoring system

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Nr. 23(1)/2015 DOI:10.1515/rrlm-2015-0009

Comparative assessment of bone regeneration by histometry and a histological scoring system

Ondine Lucaciu, Dan Gheban, Olga Soriţau, Mihaela Băciuţ, Radu Septimiu Câmpian, Grigore Băciuţ

Abstract:

Objective: The aim of this research is to evaluate the value of the histological score based on a histological record compared to the histometry for monitoring cranial bone defect healing. Methods: We designed a case -control study with a control and a study group. For a number of 60 CD1 mice representing the study group, a bone defect in the cranial bone was surgically induced and grafted with bone grafts obtained by tissue engineering. Bone grafts were obtained using embryonic stem cells seeded on a scaffold obtained from the red deer antler, and osteogenic basal and complex medium was used as differentiation medium. For other 30 CD1 mice representing the control group, a bone defect in the cranial bone was induced and left to heal without grafts. The regeneration process was assessed after 2 and 4 months using the histological healing scoring system and histometry. Results: The healing score was statistically significantly correlated with the defect size obtained by means of histometry (p<0.001). The evaluation of the parameters comprised in the healing score shows that regeneration of the bone diastasis was the most advanced in the group sacrificed at 4 months after plasty, which employed embryonic stem cells, a complex osteogenic differentiation medium and deer antler as scaffold. Conclusion: histological method based on a histological score is a valuable quantification system of bone regeneration comparable to histometry. Clinical Relevance: This study proves that the presented histological score can help the clinician in the process of bone regeneration evaluation.

Keywords: tissue engineering, histometry, bone healing, stem cells, histological scoring system

Received: 14.8.2014
Accepted: 2.3.2015
Published: 12.3.2015

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Lucaciu O, Gheban D, Soriţau O, Băciuţ M, Câmpian RS, Băciuţ G. Comparative assessment of bone regeneration by histometry and a histological scoring system. Rev Romana Med Lab. 2015;23(1):31-45. DOI:10.1515/rrlm-2015-0009