RRML - Precipitating factors of thrombotic events in patients with hereditary thrombophilia

Main page
News
RJLabM Credits
Archive
- Current issue
- Ahead of print
- List of published issues
- 2024
  - Nr.4/2024
  - Nr.3/2024
  - Nr.2/2024
  - Nr.1/2024
  - Supplement 1/2024
- 2023
  - Nr.4/2023
  - Nr.3/2023
  - Nr.2/2023
  - Nr.1/2023
  - Supplement 1/2023
- 2022
  - Nr.4/2022
  - Nr.3/2022
  - Nr.2/2022
  - Nr.1/2022
  - Supplement 1/2022
- 2021
  - Nr.4/2021
  - Nr.3/2021
  - Nr.2/2021
  - Nr.1/2021
- 2020
  - Nr.4/2020
  - Nr.3/2020
  - Nr.2/2020
  - Nr.1/2020
  - Supplement 1/2020
- 2019
  - Nr.4/2019
  - Nr.3/2019
  - Nr.2/2019
  - Nr.1/2019
  - Supplement 1/2019
- 2018
  - Nr.4/2018
  - Nr.3/2018
  - Nr.2/2018
  - Nr.1/2018
  - Supplement 1/2018
  - Supplement 2/2018
  - Supplement 3/2018
- 2017
  - Nr.4/2017
  - Nr.3/2017
  - Nr.2/2017
  - Nr.1/2017
  - Supplement 1/2017
- 2016
  - Nr.4/2016
  - Nr.3/2016
  - Nr.2/2016
  - Nr.1/2016
  - Supplement 1/2016
- 2015
  - Nr.4/2015
  - Nr.3/2015
  - Nr.2/2015
  - Nr.1/2015
  - Supplement 1/2015
- 2014
  - Nr.4/2014
  - Nr.3/2014
  - Nr.2/2014
  - Nr.1/2014
  - Supplement 1/2014
- 2013
  - Nr.4/2013
  - Nr.3/2013
  - Nr.2/2013
  - Nr.1/2013
  - Supplement 1/2013
- 2012
  - Nr.4/2012
  - Nr.3/2012
  - Nr.2/2012
  - Nr.1/2012
  - Supplement 1/2012
- 2011
  - Nr.4/2011
  - Nr.3/2011
  - Nr.2/2011
  - Nr.1/2011
  - Supplement 1/2011
- 2010
  - Nr.4/2010
  - Nr.3/2010
  - Nr.2/2010
  - Nr.1/2010
  - Supplement 1/2010
- 2009
  - Nr.4/2009
  - Nr.3/2009
  - Nr.2/2009
  - Nr.1/2009
  - Supplement 1/2009
- 2008
  - Nr.4/2008
  - Nr.3/2008
  - Nr.2/2008
  - Nr.1/2008
  - Supplement 1/2008
- 2007
  - Nr.4/2007
  - Nr.3/2007
  - Nr.2/2007
  - Nr.1/2007
- 2006
  - Nr.4/2006
  - Nr.3/2006
  - Nr.2/2006
  - Nr.1/2006
- 2005
  - Nr.1/2005
Instructions for authors
Online applications
- Send an article
- Online payments
Editorial
About us
Links

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Top 10 downloaded articles - November 2024 -

Towards appropriate training f...	31
Recomandările naționale ale ...	28
Biomarkers of acute kidney inj...	23
A comprehensive review of glyc...	20
Agreement between different eG...	19
Investigation of cytokine chan...	19
Expressions of vascular endoth...	17
Role of Th1/Th2 imbalance medi...	16
Small patients, big challenges...	9
The frequency of EGFR gene mut...	8

Concept, Design & Programming
Dr. Adrian Man

Nr. 6(1)/2007

Precipitating factors of thrombotic events in patients with hereditary thrombophilia

Rodica Mioara Păcurar, Diana Lungeanu, Elena Doina Nicola, Cristina Gheorghiu, Hortensia Ioniţă

Abstract:

Genetic mutations in hereditary thrombophilia are permanent prothrombotic risk factors in affected patients. This study presents the role of precipitating, circumstantial factors in triggering thrombotic events in patients with hereditary thrombophilia. Eighty-seven patients with at least one hereditary abnormality were entered (protein S, protein C and/or antithrombin deficiency, activated protein C resistance, high activity of factor VIII and hyperhomocysteinemia). Until the moment of enrolment, these patients had presented 164 thrombotic events, 83 (50.61%) associated with circumstantial triggers: prolonged ortostatism, thrauma, surgery, oral contraceptives, bed immobilisation over 14 days, train travel over eight hours, birth. Type and age of the first thrombotic event, presence or absence of implied trigger factors and type of thrombophilic hereditary risk factors were analysed. Conclusions: 1. irrespective of the type of anomaly, thrombotic events in patients with hereditary thrombophilia may be spontaneous or triggered by circumstantial factors to an equal degree; 2. the presence of circumstantial factors may trigger the first thrombotic event earlier during patient’s lifetime; 3. proper counselling of the thrombophilic patients in order to avoid circumstantial risk factors may prevent a thrombotic event.

Keywords: thrombophilia,circumstantial factors,counselling.

Download full text PDF
(355 KB)

Păcurar RM, Lungeanu D, Nicola ED, Gheorghiu C, Ioniţă H. Precipitating factors of thrombotic events in patients with hereditary thrombophilia. Rev Romana Med Lab. 2007;6(1):25-33