RRML - Evaluation of the pathogenicity of microorganisms involved in infective endocarditis by experimental disease

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Concept, Design & Programming
Dr. Adrian Man

Nr. 19(1)/2011

Evaluation of the pathogenicity of microorganisms involved in infective endocarditis by experimental disease

Adrian Man, Bogdan Cordoş, Anca Mare, Edit Székely, Felicia Toma, Minodora Dobreanu, Radu Deac, Lidia Man, Monica Străuţ

Abstract:

Infective endocarditis (IE) is a condition that became a public health problem, due to changes in its etiologic spectrum and to the involvement of resistant bacterial strains or of strains with increased virulence. The experimental animal model allows the assessment of certain pathologic changes that resembles those associated to this infection in humans. The aim of this experimental study is the evaluation of the virulence of the main bacterial species isolated from hospital and community and of the mechanical risk factors in IE pathogenesis. Induction of cardiac lesions in rabbits required surgery, consisting in placing a polyurethane catheter through the carotid artery. The working steps are described in detail. For inoculation we used Staphylococcus aureus strains, Enterococcus spp. strains and viridans group streptococci. Most animals with lesions induced by cardiac catheterization developed endocardic vegetations. S. aureus strains induced the most intense colonization, followed by Enterococcus faecalis strain and Enterococcus faecium strain. The average weight of vegetations was higher for E. faecalis than for S. aureus or E. faecium. Viridans group streptococci did not induced IE. Non-catheterized but inoculated animals did not develop endocarditis lesions. The mechanical irritation of the heart valve is a trigger factor in the pathogenesis of infective endocarditis, the most intense colonization of vegetation being caused by S. aureus, followed by Enterococcus spp.

Keywords: endocarditis,experimental disease,colonization

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Man A, Cordoş B, Mare A, Székely E, Toma F, Dobreanu M, et al. Evaluation of the pathogenicity of microorganisms involved in infective endocarditis by experimental disease. Rev Romana Med Lab. 2011;19(1):17-25