RRML - Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

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Nr. 24(4)/2016 DOI:10.1515/rrlm-2016-0037

Short communication

Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

Liu Bin, Meng Zhang, Liu Lixia, Zang Aimin, Yang Hua, Shang Yanhong, Yang Yang, Gao Feng, Liu Bo, Zhang Yonggang, Tian Huiping

Correspondence should be addressed to: Meng Zhang

Abstract:

Background: MiRNA-30c was a tumor suppressor in several human cancers, however, its association with clinicopathological features and prognosis in colorectal cancer (CRC) is unclear. Materials and Methods: The expression level of miRNA-30c in 192 pairs of colorectal cancer and adjacent normal tissues was detected by Quantitative RT-PCR, the association between miRNA-30c expression and clinical characteristics and prognosis were statistically analyzed. Results: miRNA-30c was significantly lower in CRC tissues specimens compared with matched normal adjacent tissue (P<0.001). MiRNA-30c was positively correlated with tumor size (P=0.012), TMN stage (P=0.002) and lymph node metastasis (P=0.004). The univariate analysis showed CRC patients with low miRNA-30c had distinctly shorter overall survival (P<0.001) than patients with high miRNA-30c expression level. The multivariate analysis was performed and informed that low miRNA-30c expression (P<0.001) might be an independent prognostic predictor for poor prognosis. Conclusion: miRNA-30c could predict the prognosis of colorectal cancer which is helpful to choose reasonable treatment measures.

Keywords: Colorectal cancer, miRNA-30c, Quantitative RT-PCR, Overall survival

Received: 7.6.2016
Accepted: 6.10.2016
Published: 10.10.2016

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Bin L, Zhang M, Lixia L, Aimin Z, Hua Y, Yanhong S, et al. Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients. Rev Romana Med Lab. 2016;24(4):369-75. DOI:10.1515/rrlm-2016-0037