 |
|
- Main page
- News
- RJLabM Credits
- Archive
- Instructions for authors
- Online applications
- Editorial
- About us
-
Links
- Committee on Publication Ethics (COPE)
- International Committee of Medical Journal Editors
- Acta Marisiensis Seria Medica
- Bacteriologia, Virusologia, Parazitologia, Epidemiologia
- Biochemia Medica
- Clinical Chemistry and Laboratory Medicine
- Clinical Chemistry
- Clinica Chimica Acta
- Documenta Haematologica
- Romanian Journal of Morphology and Embryology
- Biostatistics and web search strategies (Romanian)
- How to spot a statistical problem
- Statistical Analyses and Methods in the Published Literature
ISSN online: 2284-5623
ISSN-L: 1841-6624
Rejection rate (2020): 75%
Journal Metrics
Impact Factor 0.5 Five Year Impact Factor 0.5 JCI 0.12
|
Top 10 downloaded articles - August 2025 - |
|
| Tissue protection immunohistoc... | 1 |
| Basophil activation test using... | 1 |
| Laboratory techniques in multi... | 1 |
| Diagnostic value of combinatio... | 1 |
Log in
Concept, Design & Programming
Dr. Adrian Man
Research article The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis Neslihan Sungur, Sabahattin Muhtaroğlu, Didem Barlak Keti, Hakan Imamoğlu
Correspondence should be addressed to: Neslihan Sungur
Abstract: Background: Coronary computed tomography angiography (CCTA) is the gold standard method for detecting the presence of coronary plaque and stenosis in atherosclerosis. However, the nephrotoxic effects of contrast agents applied during angiography and the adverse effects of radiation are known. Alternative diagnostic tools are always needed to evaluate coronary arteries. Therefore, combining the results of CCTA with Lipoprotein-associated phospholipase A2 (Lp-PLA2) and Matrix metalloproteinase (MMP)-9, which are thought to be associated with atherosclerotic plaque, may reduce cardiovascular events in patients with suspected atherosclerosis. Methods: In the serum samples collected from the control group and patients, CRP, triglyceride, total cholesterol, LDL-C, HDL-C, Lp-PLA2, and MMP-9 levels were analyzed. Receiver Operating Characteristic (ROC) analysis was applied to determine optimal cut-off values in identifying patients with coronary plaque or stenosis. The significance level was accepted as p<0.05. Results: Fifty-four patients with suspected CAD who underwent both CCTA and serum Lp-PLA2 and MMP9 measurements were evaluated. Patients in the stenosis/plaque group had a significantly higher LpPLA2 and MMP-9 than the control group. Lp-PLA2 is positively associated with MMP-9 and MMP-9 with non-HDL. Except for Lp-PLA2 and CRP, sdLDL is associated with all assayed parameters. Lp-PLA2 and MMP-9 had 91.7% and 100% sensitivity in identifying patients with coronary plaque or stenosis at cut-off values of 183.34 and 24, respectively. MMP-9 and sdLDL-C had 100% and 92.9% specificity at cut-off values of 24 and 48.1. Conclusions: By evaluating Lp-PLA2, MMP-9, sdLDL-C levels together with CT angiography findings, it is thought that these parameters can be used as an alternative to CT in controlling patients at risk and patients who have undergone cardiological intervention before. Keywords: coronary CT angiography, coronary plaque, Lp-PLA2, MMP-9, sdLDL
Received: 16.4.2025 |
|||||
|
Download full text PDF (557 KB) |
||||
|
Sungur N, Muhtaroğlu S, Keti DB, Imamoğlu H. The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis. Rev Romana Med Lab. 2025;33(3):145-50. DOI:10.2478/rrlm-2025-0015
|
|||||