RRML - Proximal tubule dysfunction in renal diseases - diagnostic significance of proteomics and biomarkers

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Nr. 20(2)/2012

Proximal tubule dysfunction in renal diseases - diagnostic significance of proteomics and biomarkers

Ligia Petrica, A. Gluhovschi, Cristina Gluhovschi, Florica Gadalean, C. Balgradean, Cristina Groza, Silvia Velciov

Abstract:

At present time, clinical practice requires advanced studies of plasma and urinary proteomics which should allow the identification, selection, and implementation of plasma and urinary biomarkers useful in the diagnosis of acute and chronic renal diseases, as well as of drug-induced nephrotoxicity. The importance of these biomarkers also resides in their prognostic value and the posibility of their repeated and dinamic assessment, in order to detect early the progression of an acute renal disease to chronic kidney disease, and of the later one to its final stages.In the present paper urinary biomarkers and proteomics, and their application in the accurate diagnosis of tubular lesions in various settings, (such as early diabetic nephropathy, acute kidney injury, glomerular nephropathies, polycystic kidney disease, renal transplantation, Balkan endemic nephropathy, and preeclampsia), are discussed in view of the clinical expertise of the authors in this field.

Keywords: biomarkers,proteomics,tubular lesions

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Petrica L, Gluhovschi A, Gluhovschi C, Gadalean F, Balgradean C, Groza C, et al. Proximal tubule dysfunction in renal diseases - diagnostic significance of proteomics and biomarkers. Rev Romana Med Lab. 2012;20(2):97-107