RRML - The Role of MiR-124 in Bladder Cancer

RRML - The Role of MiR-124 in Bladder Cancer – A Review of the Literature

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Nr. 29(1)/2021 DOI:10.2478/rrlm-2021-0001

Review

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Costin Petcu, Catalin Baston, Emil Angelescu, Maria Mirela Iacob, Ileana Constantinescu, Ioanel Sinescu

Correspondence should be addressed to: Catalin Baston

Abstract:

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.

Keywords: bladder cancer, miR-124, microRNA, miR-124 target, miRNAs

Received: 30.6.2020
Accepted: 19.11.2020
Published: 9.12.2020

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Petcu C, Baston C, Angelescu E, Iacob MM, Constantinescu I, Sinescu I. The Role of MiR-124 in Bladder Cancer – A Review of the Literature. Rev Romana Med Lab. 2021;29(1):9-18. DOI:10.2478/rrlm-2021-0001