RRML - Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion
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Nr. 30(3)/2022 DOI:10.2478/rrlm-2022-0024
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Research article

Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion

Hebin Liu, Yujuan Song, Menglan Zhou, Xiaoling Yao

Correspondence should be addressed to: Hebin Liu

Abstract:

Background: To investigate the associations of serum vitamin D and Fok I polymorphism of its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA). Methods: Ninety URSA patients and another 104 healthy pregnant women were selected as URSA and control groups, respectively. 25-Hydroxyvitamin D [25-(OH)D] level was detected by chemiluminescence. VDR gene Fok I polymorphism was analyzed by PCR, and the distribution of genotype frequency was calculated by Hardy-Weinberg equilibrium test. Association between Fok I polymorphism and susceptibility to URSA was investigated by logistic regression analysis. Results: Gestational age, uterine height, waist circumference, 25-(OH)D level and proportions of Fok I FF and Ff genotypes were significantly lower in the URSA group (P<0.05). Compared with ff genotype, risk of URSA reduced for Ff and FF genotypes. Compared with allele f, risk of URSA was lower for allele F. 25-(OH)D level of ff genotype was significantly lower in the URSA group, which was lower than that of FF genotype (P<0.05). Compared with women with 25-(OH)D level >30 ng/mL and F allele (FF+Ff), the risk of URSA increased 2.45-, 2.43- and 5.34-fold for those with 25-(OH)D level >30 ng/mL and ff genotype, with 25-(OH)D level ≤30 ng/mL, and with ff genotype and 25-(OH)D level ≤30 ng/mL, respectively. Conclusions: The 25-(OH)D level of the URSA group was significantly lower than that of normal pregnant women. Probably, VDR gene Fok I polymorphism is associated with URSA occurrence, and allele F decreases the risk. The risk of URSA dramatically increases in women with ff genotype and 25-(OH)D deficiency.

Keywords: vitamin D; receptor gene; polymorphism; recurrent spontaneous abortion

Received: 12.10.2021
Accepted: 20.5.2022
Published: 7.6.2022

 
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How to cite
Liu H, Song Y, Zhou M, Yao X. Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion. Rev Romana Med Lab. 2022;30(3):293-303. DOI:10.2478/rrlm-2022-0024