RRML - Novel DCX pathogenic variant in a girl with subcortical band heterotopia
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.493
Five Year Impact Factor 0.531
SNIP 0.373
JCI 0.17


Advanced search


Top 10 downloaded articles
- September 2022 -
 
Downregulation of hsa-miR-4328... 15
Normality assessment, few para... 11
SPP1 is a biomarker of cervica... 9
Biomarkers in heart failure: f... 8
Validation of GOD / PAP method... 7
The effect of Ulva rigida (C. ... 7
Expressions of TGF-β1 and VEG... 7
COVID-19 associated coagulopat... 6
Approaching Risk Management in... 6
Expression of serum soluble Kl... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 30(3)/2022 DOI:10.2478/rrlm-2022-0031
XML
TXT

Case report

Novel DCX pathogenic variant in a girl with subcortical band heterotopia

Sorina Mihaela Papuc, Magdalena Budisteanu, Alina Erbescu, Virgil Ionescu, Catrinel Iliescu, Carmen Sandu, Aurora Arghir

Correspondence should be addressed to: Sorina Mihaela Papuc

Abstract:

Subcortical band heterotopia (SBH), is a brain malformation defined by symmetrical and bilateral heterotopic gray matter bands localized deep within the white matter, between the cortex and lateral ventricles. SBH is the result of abnormal neuronal migration, with improper positioning of the cortical neurons. DCX gene (doublecortin), a microtubule-associated protein with essential roles in neuronal migration and differentiation during brain development, is one of the main contributors to the X-linked Lissencephaly spectrum pathogenesis (OMIM #300067). DCX variants are responsible for SBH in females and isolated lissencephaly in males. Herein, we present a 7-year-old girl with a de novo frameshift variant in DCX gene, unreported by date. The patient has focal complex seizures with onset at 23 months of age, fully controlled with medication, mild tremor and coordination impairment of fine movements and some learning difficulties, otherwise with normal development. The brain magnetic resonance imaging revealed the presence of thick SBH. Direct sequencing of DCX gene revealed a pathogenic heterozygous cytosine duplication in exon 3; this frameshift variant leads to a premature stop codon in position 164 (p.Gln160Profs*5). The variant type and its predicted consequence at protein level correlates with the severity of radiological findings. The clinical presentation of our patient is, however, milder than expected. Our research expands the mutational spectrum of DCX gene in SBH females and provides a detailed clinical and imagistic description of the patient. This paper highlights the utility of single gene sequencing as a first-tier diagnostic test of patients with gene-specific phenotypic features.

Keywords: Sanger sequencing, seizures, band heterotopia, brain magnetic resonance, abnormal cortical development

Received: 10.12.2021
Accepted: 22.6.2022
Published: 8.7.2022

 
  PDF Download full text PDF
(453 KB)
     
 
How to cite
Papuc SM, Budisteanu M, Erbescu A, Ionescu V, Iliescu C, Sandu C, et al. Novel DCX pathogenic variant in a girl with subcortical band heterotopia. Rev Romana Med Lab. 2022;30(3):345-51. DOI:10.2478/rrlm-2022-0031