RRML - Circulating amino acids as fingerprints of visceral adipose tissue independent of insulin resistance: a targeted metabolomic research in women
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Nr. 29(4)/2021 DOI:10.2478/rrlm-2021-0033
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Circulating amino acids as fingerprints of visceral adipose tissue independent of insulin resistance: a targeted metabolomic research in women

Andrada A. Muresan, Adriana Rusu, Raluca M. Pop, Camelia L. Vonica, Nicolae Hancu, Corina Bocsan, Carmen Socaciu, Cornelia G. Bala, Gabriela Roman

Correspondence should be addressed to: Andrada A. Muresan

Abstract:

Introduction: Although obesity and its biomarkers have been intensively studied, little is known about the metabolomic signature of visceral adiposity independent of insulin resistance that frequently accompanies increased levels of visceral fat. Our study aimed to investigate specific changes in amino acid (AA) levels as biomarkers of increased visceral adiposity independent of insulin resistance, in healthy subjects. Methods: Forty-two adult women were included in this cross-sectional study. Serum samples were analyzed by AAs targeted metabolomics according to their visceral fat area (<100 cm2 and ≥100 cm2). Results: By corrected t-test and supervised partial least-squares discriminant analysis (PLS-DA) we identified 4 AAs that were significantly higher in the group with higher visceral fat: proline (variable importance in the projection [VIP] predicted value: 1.97), tyrosine (VIP: 2.21), cysteine (VIP: 1.19), isoleucine (VIP: 1.04; p-values <0.05). Also, glycine was significantly lower in the group with higher visceral fat (VIP: 1.65; p-value <0.05). All AAs identified were associated with visceral fat independent of homeostatic model assessment for insulin resistance (p-value for regression coefficients <0.05). Conclusion: Metabolic pathways that might be disrupted in persons with increased visceral fat are phenylalanine, tyrosine, and tryptophan biosynthesis; tyrosine metabolism; glycine, serine, and threonine metabolism; glyoxylate and dicarboxylate metabolism, and cysteine and methionine metabolism.

Keywords: metabolomics; amino acids; visceral fat; insulin resistance

Received: 10.9.2021
Accepted: 5.10.2021
Published: 10.10.2021

 
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How to cite
Muresan AA, Rusu A, Pop RM, Vonica CL, Hancu N, Bocsan C, et al. Circulating amino acids as fingerprints of visceral adipose tissue independent of insulin resistance: a targeted metabolomic research in women. Rev Romana Med Lab. 2021;29(4):439-51. DOI:10.2478/rrlm-2021-0033