RRML - Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2020): 1.027

Rejection rate (2020): 75%

Română English


Clarivate analytics (ISI) Impact factor


Advanced search


Top 10 downloaded articles
- September 2021 -
 
Insights into Innate Immune Re... 22
Correction factor between two ... 13
The effects of microwave radia... 10
The Expression of miR-155-5p a... 9
Genetic Diagnostic Approaches ... 7
Romanian Review of Laboratory ... 6
Essentials in the diagnosis of... 6
Atellica CH 930 chemistry anal... 6
Molecular diagnostic of Ureapl... 5
Prognostic value of serum lact... 5

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 29(2)/2021 DOI:10.2478/rrlm-2021-0007
XML
TXT

Research article

Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation

Didem Barlak Keti, Sabahattin Muhtaroglu

Correspondence should be addressed to: Didem Barlak Keti

Abstract:

Introduction: Many laboratories utilize Friedewald formula (FF) to analyze LDL cholesterol levels of patients including diabetes mellitus (DM). Therefore, it is essential to consider the coherence of results acquired by FF and direct measurement. The number of studies that investigated the effect of lipid parameters, especially TG/HDL cholesterol ratio, on the difference between the two methods is limited. The study was designed to compare LDL cholesterol values obtained by using FF with direct measurement, and to evaluate the relationship between diabetes regulation and lipid profile. Material and Methods: In the cross-sectional study, 529 type 2 DM patients and 1703 non-DM subjects were divided into four groups regarding TG concentrations. Unlike other studies, the study focuses on direct LDL (DLDL) cholesterol levels obtained with the help of different DLDL cholesterol kits (n=20). The correlations were implemented between HbA1c and lipid profiles. Results: It was determined that the bias% was over 10% in 24% of patients with 100-199 mg/dL TG levels. The parameter revealed that the most significant difference and the strongest correlation with HbA1c was TG/HDL cholesterol ratio in patients with type 2 DM. Conclusions: In patients with type 2 DM, even if it was TG <200 mg/dL, LDL calculated with FF should be evaluated together with the TG/HDL cholesterol ratio. Otherwise, direct measurement can be recommended. This ratio is related to diabetes regulation and may be used to monitor patients.

Keywords: Friedewald formula, LDL cholesterol, type 2 diabetes mellitus

Received: 26.8.2020
Accepted: 27.12.2020
Published: 28.1.2021

 
  PDF Download full text PDF
(509 KB)
     
 
How to cite
Keti DB, Muhtaroglu S. Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation. Rev Romana Med Lab. 2021;29(2):179-87. DOI:10.2478/rrlm-2021-0007