RRML - The predictive role of platelet to lymphocyte ratio in the occurrence of anastomotic complications following gastric resections for neoplasia – single centre experience
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2019): 0.945

Rejection rate (2016): 55%

Română English


Clarivate analytics (ISI) Impact factor


Advanced search


Top 10 downloaded articles
- August 2020 -
 
Romanian Review of Laboratory ... 8
Metabolomic biomarkers of poly... 6
Mucopolysaccharidosis type I -... 4
Carbapenemase Producing Entero... 3
Total Errors of TSH results by... 3
High frequency of BRCA recurre... 3
Evaluation of Diagnostic Tests... 2
Plasma levels of resistin pred... 2
Multiplex ligation dependent p... 2
The usefulness of neutrophil/l... 2

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 28(2)/2020 DOI:10.2478/rrlm-2020-0011
XML
TXT

Research article

The predictive role of platelet to lymphocyte ratio in the occurrence of anastomotic complications following gastric resections for neoplasia – single centre experience

Călin Molnar, Cosmin Lucian Nicolescu, Marian Botoncea, Vlad-Olimpiu Butiurca, Bogdan Andrei Suciu, Ioana Hălmaciu, Liana Bianca Grigorescu, Septimiu Voidazan

Correspondence should be addressed to: Cosmin Lucian Nicolescu

Abstract:

Introduction: Our study investigated the importance of inflammation markers – ratio of platelets and lymphocytes (PLR), ratio of neutrophils and lymphocytes (NLR) and ratio of lymphocytes and monocytes (LMR) – as predictive markers in the occurrence of fistula or stenosis in patients diagnosed with gastric adenocarcinoma who underwent gastric resections. Materials and Methods: We conducted a retrospective study of 178 patients diagnosed with gastric adenocarcinoma. The included patients were divided into 3 groups: group 1 (77 patients, who underwent lower gastrectomy), group 2 (27 patients, who had upper polar gastrectomy otherwise known as proximal gastrectomy), group 3 (74 patients, who underwent total gastrectomy). Ratios of PLR, NLR, respectively LMR were calculated for all patients. Results: Out of 178 patients 52 (29.2%) developed postoperative stenosis and 16 patients (9.0%) had postoperative fistulae. The occurrence of anastomotic stenosis was associated with significantly higher preoperative platelet counts (p=0.043) and PLR values (p=0.023). ROC curve analysis indicated that the optimal PLR value for the prediction of gastric stenosis was 198.4 (AUC= 0.609, sensitivity: 59.6%, specificity: 61.9%). For the prediction of fistulization PRL also displayed the highest performance among the analyzed hematological parameters (AUC=0.561, sensitivity: 43.7%, specificity: 81.5%, cut-off value 116.6. Conclusion: Our study indicates the importance of PLR as e predictive factor in the occurrence of anastomotic complications (fistulae or stenosis) immediately following surgery in patients with gastric adenocarcinoma that undergo gastric resections. Further prospective studies on larger groups of patients are required, considering that PLR, NLR and LMR will be key markers in the clinical management of patients with gastric cancer.

Keywords: gastric adenocarcinoma, neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, platelet/lymphocyte ratio

Received: 5.12.2019
Accepted: 2.3.2020
Published: 10.3.2020

 
  PDF Download full text PDF
(391 KB)
     
 
How to cite
Molnar C, Nicolescu CL, Botoncea M, Butiurca VO, Suciu BA, Hălmaciu I, et al. The predictive role of platelet to lymphocyte ratio in the occurrence of anastomotic complications following gastric resections for neoplasia – single centre experience. Rev Romana Med Lab. 2020;28(2):185-94. DOI:10.2478/rrlm-2020-0011