RRML - Total antioxidant status as marker of oxidative stress in infants with intrauterine growth restriction

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Nr. 28(2)/2020 DOI:10.2478/rrlm-2020-0013

Short communication

Total antioxidant status as marker of oxidative stress in infants with intrauterine growth restriction

Șadiye-Ioana Scripcariu, Andreea Avasiloaiei, Demetra Socolov, Elena Mihălceanu, Daniela-Cristina Dimitriu, Mihaela Moscalu, Maria Stamatin

Correspondence should be addressed to: Andreea Avasiloaiei

Abstract:

Aim: The aim of this study is to identify correlations between total antioxidant status values of mothers and their infants and compare these values in accordance to the presence or absence of intrauterine growth restriction. Material and methods: This is a prospective, comparative study performed over a period of 3 years on a number of 52 infants and their mothers. Thirty-six of them had intrauterine growth restriction and 16 were appropriate for their gestational age and were used for comparative purposes. General information regarding the mother, infant and pregnancy were recorded. In addition, total antioxidant status was assessed from blood samples, taken right before delivery from mothers and from the cord blood in infants. Results: We found significant differences between total antioxidant status both between mothers and neonates with IUGR (intrauterine growth restriction) versus without IUGR (p=0.018, and p<0.001, respectively). In addition, in both groups, there was a significant direct correlation between maternal and neonatal values of serum total antioxidant status (TAS) (p<0.001). In conclusion, we can say that TAS values, as an important marker of the oxidative status of patients, are correlated with the presence of IUGR and values recorded from blood samples of the mother may be predictive for the oxidative status of the infant, thus of IUGR.

Keywords: neonatal, total oxidative status, intrauterine growth restriction, oxidative status

Received: 19.8.2019
Accepted: 28.1.2020
Published: 13.2.2020

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Scripcariu ȘI, Avasiloaiei A, Socolov D, Mihălceanu E, Dimitriu DC, Moscalu M, et al. Total antioxidant status as marker of oxidative stress in infants with intrauterine growth restriction. Rev Romana Med Lab. 2020;28(2):145-52. DOI:10.2478/rrlm-2020-0013