RRML - Genotype comparison of Candida albicans isolates from different clinical samples

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ISSN-L: 1841-6624

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Dr. Adrian Man

Nr. 27(3)/2019 DOI:10.2478/rrlm-2019-0027

Research article

Genotype comparison of Candida albicans isolates from different clinical samples

Andra-Cristina Bostănaru, Irina Roșca, Bogdan Minea, Valentin Năstasă, Liliana Foia, Iosif Marincu, Mihai Mares, Ovidiu-Alexandru Mederle

Correspondence should be addressed to: Mihai Mares


Background: Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on the correlation between the infection site and the genotypes of Candida albicans strains isolated from Romanian patients. Methods: A total number of 301 isolates from different clinical sites were investigated in terms of genotype determination. Results: The isolates were clustered in three groups according to their genotype: 55.81% showed genotype A, 14.62% genotype B, and 29.57% genotype C. Conclusions: No significant correlation was found between the genotype and the infection site, but a significant correlation was found between genotype C and isolates from HIV patients proving that C. albicans pathogenicity probably relies on factors related to the host.

Keywords: C. albicans, clinical source, genotype C, HIV-patients, Romania

Received: 22.1.2019
Accepted: 15.4.2019
Published: 18.6.2019

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How to cite
Bostănaru AC, Roșca I, Minea B, Năstasă V, Foia L, Marincu I, et al. Genotype comparison of Candida albicans isolates from different clinical samples. Rev Romana Med Lab. 2019;27(3):327-32. DOI:10.2478/rrlm-2019-0027