RRML - Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study
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Nr. 27(2)/2019 DOI:10.2478/rrlm-2019-0016
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Research article

Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study

Fatemeh Sadabadi, Alireza Heidari-Bakavoli, Habibollah Esmaily, Susan Darroudi, Maryam Tayefi, Zahra Asadi, Seyed Mohammad Reza Parizadeh, Shima Tavalaie, Najmeh Malekzadeh, Kiana Hosseinpour Moghaddam, Azam Rastgar Moghadam, Amir Hosein Sahebkar, Narges Fereydouni, Elham Barati, Mahmoudreza Azarpazhooh, Seyyed Javad Hosseini, Mohammad Tayyebi, Mahmoud Ebrahimi, Gordon A Ferns, Majid Ghayour-Mobarhan, Mohsen Mouhebati

Correspondence should be addressed to: Majid Ghayour-Mobarhan, Mohsen Mouhebati

Abstract:

Heat shock protein 27 (HSP27) is an intracellular chaperone constitutively expressed in many cell types including cardio myocytes and endothelial cells. Circulating levels of HSP27 and anti-HSP27 antibody are higher in patients with CVD. Anti-HSP27 antibody concentrations were also reported to be increased in atherogenesis. We aimed to evaluate serum anti-HSP27 antibody titers in individuals with, or without, MetS in the MASHAD study cohort with large sample size in 6,568 subjects. Methods: Participants with MetS were identified from MASHAD cohort (n=3358) using the IDF criteria, and the control group were those individuals who did not meet these criteria (n=3210). In-house enzyme-linked immune sorbent assay (ELISA) method was used for measuring Anti-HSP27 antibody levels. The two groups were matched for age, sex and smoking habit. Results: As expected, there were significant differences in height (p= 0.004), waist and hip circumference, weight, BMI, systolic and diastolic blood pressure, TGs, TC, HDL-C, Hs-CRP, glucose, with the presence of diabetes mellitus, hypertension, hyperlipidemia (p<0.001) between the two groups. Serum HSP27 antibody titers did not show significant difference between the groups with and without metabolic syndrome (p= 0.740). Conclusion: In conclusion, our results revealed serum anti-HSP27 antibody titers were not statistically different between individuals with and without MetS. However, it is possible that drug treatment may affect antibody titers and confound our findings in this population sample.

Keywords: serum anti-HSP27 antibody, Metabolic syndrome, MASHAD study cohort

Received: 15.9.2018
Accepted: 9.2.2019
Published: 15.4.2019

 
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How to cite
Sadabadi F, Heidari-Bakavoli A, Esmaily H, Darroudi S, Tayefi M, Asadi Z, et al. Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study. Rev Romana Med Lab. 2019;27(2):179-87. DOI:10.2478/rrlm-2019-0016