RRML - Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2020): 1.027

Rejection rate (2020): 75%

Română English


Clarivate analytics (ISI) Impact factor


Advanced search


Top 10 downloaded articles
- November 2021 -
 
Cell Cycle Regulatory CCND1 G8... 19
COVID-19 associated coagulopat... 19
Romanian Review of Laboratory ... 13
The Effect of Resveratrol on S... 11
Acquired Angioedema Due to C1 ... 10
Circulating amino acids as fin... 10
Mutations in the KRAS gene as ... 9
Evaluation of Plasma AA/DHA+EP... 6
Genetic Diagnostic Approaches ... 6
Atellica CH 930 chemistry anal... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 26(1)/2018 DOI:10.2478/rrlm-2018-0004
XML
TXT

Short communication

Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients

Adina Huțanu, Smaranda Maier, Rodica Bălaşa, Oana Roxana Oprea, Ştefan Barbu, Septimiu Voidăzan, Minodora Dobreanu

Correspondence should be addressed to: Smaranda Maier

Abstract:

Background: The aim of the study was to determine the utility of plasma NfH in correlation with serum hsCRP for severity and short-term functional outcome prediction after ischemic stroke. Methods: 124 patients and 40 healthy controls were enrolled, serial plasma neurofilament heavy chains and hsCRP concentrations were measured and evaluated for TOAST subtype, stroke severity and functional outcome at discharge. Results: Serum level of hsCRP was significantly higher in patients versus controls (p<0.05) with no difference between TOAST subtypes. Plasma NfH concentration on day 5 was higher in CE stroke compared to LAA group and SVO group. A positive correlation between NfH levels on day 5 and mRS at discharge (r=0.304, p=0.001) and a gender stratification of hsCRP and mRS at discharge was found. Values of 6.04 mg/l for hsCRP and 46.4 ng/ml for NfH were found predictive for unfavorable short-term outcome, but after adjusting for age, sex and stroke severity, the prediction power was lost. Conclusions: Plasma concentration of NfH shows a significant increase over the first five days after ischemic stroke, in correlation with inflammatory status and short-term evolution.

Keywords: phosphorylated neurofilament heavy chains, ischemic stroke

Received: 12.12.2017
Accepted: 10.1.2018
Published: 15.1.2018

 
  PDF Download full text PDF
(307 KB)
  PDF Download erata
(221 KB)
     
 
How to cite
Huțanu A, Maier S, Bălaşa R, Oprea OR, Barbu Ş, Voidăzan S, et al. Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients. Rev Romana Med Lab. 2018;26(1):59-64. DOI:10.2478/rrlm-2018-0004