RRML - Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- April 2024 -
 
A comprehensive review of Prof... 24
Recomandarea comună EFLM-COLA... 13
Monocyte to high-density lipop... 9
Anti-thyroid peroxidase (TPO) ... 9
Understanding the key differen... 7
Understanding the pathogenesis... 7
Function of the S1P pathway in... 6
Predictive value of expression... 5
The importance of tumor marker... 4
Romanian Review of Laboratory ... 4

Log in

Concept, Design & Programming
Dr. Adrian Man
   
 
Nr. 26(1)/2018 DOI:10.2478/rrlm-2018-0004
XML
TXT

Short communication

Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients

Adina Huțanu, Smaranda Maier, Rodica Bălaşa, Oana Roxana Oprea, Ştefan Barbu, Septimiu Voidăzan, Minodora Dobreanu

Correspondence should be addressed to: Smaranda Maier

Abstract:

Background: The aim of the study was to determine the utility of plasma NfH in correlation with serum hsCRP for severity and short-term functional outcome prediction after ischemic stroke. Methods: 124 patients and 40 healthy controls were enrolled, serial plasma neurofilament heavy chains and hsCRP concentrations were measured and evaluated for TOAST subtype, stroke severity and functional outcome at discharge. Results: Serum level of hsCRP was significantly higher in patients versus controls (p<0.05) with no difference between TOAST subtypes. Plasma NfH concentration on day 5 was higher in CE stroke compared to LAA group and SVO group. A positive correlation between NfH levels on day 5 and mRS at discharge (r=0.304, p=0.001) and a gender stratification of hsCRP and mRS at discharge was found. Values of 6.04 mg/l for hsCRP and 46.4 ng/ml for NfH were found predictive for unfavorable short-term outcome, but after adjusting for age, sex and stroke severity, the prediction power was lost. Conclusions: Plasma concentration of NfH shows a significant increase over the first five days after ischemic stroke, in correlation with inflammatory status and short-term evolution.

Keywords: phosphorylated neurofilament heavy chains, ischemic stroke

Received: 12.12.2017
Accepted: 10.1.2018
Published: 15.1.2018

 
  PDF Download full text PDF
(307 KB)
  PDF Download erata
(221 KB)
     
 
How to cite
Huțanu A, Maier S, Bălaşa R, Oprea OR, Barbu Ş, Voidăzan S, et al. Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients. Rev Romana Med Lab. 2018;26(1):59-64. DOI:10.2478/rrlm-2018-0004