RRML - Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2020): 1.027

Rejection rate (2020): 75%

Română English


Clarivate analytics (ISI) Impact factor


Advanced search


Top 10 downloaded articles
- November 2021 -
 
Cell Cycle Regulatory CCND1 G8... 19
COVID-19 associated coagulopat... 19
Romanian Review of Laboratory ... 13
The Effect of Resveratrol on S... 11
Acquired Angioedema Due to C1 ... 10
Circulating amino acids as fin... 10
Mutations in the KRAS gene as ... 9
Evaluation of Plasma AA/DHA+EP... 6
Genetic Diagnostic Approaches ... 6
Atellica CH 930 chemistry anal... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 26(1)/2018 DOI:10.2478/rrlm-2018-0003
XML
TXT

Research article

Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke

Abdullah Sivrikaya, Serefnur Ozturk, Hakan Ekmekci, Aslıhan Sağlam, Sedat Abusoglu, Ali Unlu

Correspondence should be addressed to: Sedat Abusoglu

Abstract:

Introduction: Sitosterolemia, defined as phytosterolemia, is a rare autosomal recessive disease characterized by elevated blood sterol levels. Our aim was to investigate serum plant sterols, methylmalonic acid, vitamin B12, oxidized-LDL and homocysteine levels in ischemic and hemorrhagic stroke patients and healthy subjects. Material and Methods: 50 healthy subjects (without a family history of coronary artery disease) and 89 patients hospitalized in the Selcuk University neurology clinic or intensive care unit with a diagnosis of stroke were included in this study. Serum plant sterols, homocysteine and methylmalonic acid, oxidized-LDL, total cholesterol, triglycerides, HDL-Cholesterol and vitamin B12 levels were analyzed by gas chromatography-mass spectrometry, liquid-chromatography tandem mass spectrometry, commercially available ELISA kit, spectrophotometry and chemiluminescence methods, respectively. Results: Urinary methylmalonic acid/creatinine ratio (p< 0.05), serum β-sitosterol levels and β-sitosterol/ cholesterol ratio were significantly higher (p <0.01) in patients compared to the control group. There was a significant positive correlation between the serum OxLDL- methylmalonic acid, serum homocysteine- urinary methylmalonic acid /creatinine ratio, serum methylmalonic acid - Urinary methylmalonic acid (p<0.05), serum homocysteine- urinary methylmalonic acid, urinary methylmalonic acid-methylmalonic acid/creatinine ratio, serum methylmalonic acid- methylmalonic acid/creatinine ratio, serum beta-sitosterol- beta-sitosterol /cholesterol, total cholesterol-HDL, total cholesterol-LDL (p <0.01) levels and negative correlation between vitamin B12- serum methylmalonic acid (p<0.05), cholesterol-stigmasterol/cholesterol, LDL- stigmasterol/cholesterol (p <0.01) levels in the patient group. Conclusion: Our findings presented that the serum sitosterol levels were significantly higher in stroke patients compared to controls.

Keywords: sterol, stroke, oxidized LDL, methylmalonic acid, creatinine

Received: 24.8.2017
Accepted: 5.12.2017
Published: 17.12.2017

 
  PDF Download full text PDF
(572 KB)
     
 
How to cite
Sivrikaya A, Ozturk S, Ekmekci H, Sağlam A, Abusoglu S, Unlu A. Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke . Rev Romana Med Lab. 2018;26(1):51-8. DOI:10.2478/rrlm-2018-0003