RRML - Ischemic modified albumin increases in acute kidney injury

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Dr. Adrian Man

Nr. 26(1)/2018 DOI:10.2478/rrlm-2018-0002

Research article

Ischemic modified albumin increases in acute kidney injury

Cuma Mertoglu, Murat Gunay, Ali Gurel, Mehmet Gungor, Vahdet Gul

Correspondence should be addressed to: Cuma Mertoglu


Purpose: Acute kidney injury (AKI) is a severe kidney disease carrying high morbidity and mortality. An ischemic process, at the cellular level, has been detected prior to the full-blown AKI. An elevated ischemic modified albumin (IMA) was also found to be increased fast at several minutes following an ischemic process in the body. In this connection, we have investigated, in advance, the changes of IMA concentrations in patients with possible AKI. Methods: IMA and other biochemical and haematological parameters were measured in sera of thirty nine patients with AKI and of thirty eight healthy controls. AKI is defined by an increase in serum creatinine by ≥ 0.3 mg/dl in 48 hours or an increase by ≥ 1.5-fold from a known or assumed baseline. The results in the two groups were compared. Results: IMA, creatinine, blood urea nitrogen, white blood cell, neutrophil, neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) and mean platelet volume were found to be higher in patients with AKI than in healthy controls. In contrast, total protein, albumin, lymphocyte, and haemoglobin were lower in patients with AKI than in healthy controls. No significant difference was recorded in platelet counts between the two groups. Conclusion: Our results indicate that increased levels of NLR and PLR play a central role in a systemic inflammation in AKI. Monitoring serum IMA could be a useful tool in the assessment of AKI.

Keywords: Acute kidney injury, ischemic modified albumin, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, mean platelet volume

Received: 23.5.2017
Accepted: 19.11.2017
Published: 16.12.2017

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How to cite
Mertoglu C, Gunay M, Gurel A, Gungor M, Gul V. Ischemic modified albumin increases in acute kidney injury. Rev Romana Med Lab. 2018;26(1):37-43. DOI:10.2478/rrlm-2018-0002