RRML - Microbial biofilm in human health - an updated theoretical and practical insight
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2015): 0.143

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- May 2017 -
 
The frequency of Human Papillomav... 13
Rapid liquid chromatography tande... 10
Easily Available Blood Test Neutr... 10
Romanian Review of Laboratory Med... 9
Microbial biofilm in human health... 9
Wistar rats with long-term strept... 8
Complete blood count and differen... 8
Polymorphisms in autophagy genes ... 8
Platelet concentrates transfusion... 8
Can we find accessible and releva... 7

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 25(1)/2017 DOI:10.1515/rrlm-2017-0001
XML
TXT

Review

Microbial biofilm in human health - an updated theoretical and practical insight

Biofilmul microbian în medicină - o perspectivă teoretică și practică

Monica Licker, Roxana Moldovan, Elena Hogea, Delia Muntean, Florin Horhat, Luminița Baditoiu, Alexandru Florin Rogobete, Emil Tirziu, Csilla Zambori

Correspondence should be addressed to: Delia Muntean

Abstract

The term biofilm designates an aggregate of microorganisms belonging to one or more species which adhere to various surfaces but also to each another. These microbial communities are included and interconnected within an organic structure known as slime, composed of protein substances, polysaccharides, and DNA. The Center for Disease prevention and control considers infections with bacteria in biofilms among the 7 most important challenges which must be overcome in order to improve the safety of health services. The risk of microbial biofilm development exists for a long list of medical devices and equipment, as well as in certain diseases such as cystic fibrosis. An aggravating aspect is represented by the almost 1,000 times higher antimicrobial resistance of bacteria growing and multiplying within biofilms. Thus, in case of biofilm-infected medical devices, the resistance to antimicrobial treatments requires the removal of the device which essentially means the failure of the exploratory or therapeutic intervention in question. The role of microbial biofilms in medical pathology is a subject that raises interest for both researchers and clinicians in order to establish new methods for prevention and treatment of biofilms. This paper is intended as an overview in the management of microbial biofilms, presenting future insights, with technological progress in microscopy, molecular genetics, and genome analysis. Therefore the present paper will focus on describing the mechanisms involved in biofilm development, biofilm related infections, methods of detection and quantification of microbial communities and therapeutical approaches.

Keywords: biofilm; medical devices; microscopy

Received: 8.8.2016
Accepted: 26.11.2016
Published: 29.11.2016

 
  PDF Download full text PDF
(633 KB)
     
 
How to cite
Licker M, Moldovan R, Hogea E, Muntean D, Horhat F, Baditoiu L, et al. Microbial biofilm in human health - an updated theoretical and practical insight. Rev Romana Med Lab. 2017;25(1):9-26. DOI:10.1515/rrlm-2017-0001