RRML - Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- July 2019 -
 
Simultaneous FLT3, NPM1 and DN... 11
Do we really need genetic test... 7
Genotype comparison of Candida... 7
Laboratory medicine in the era... 5
Antibiotic susceptibility and ... 4
Point-of-care testing in diabe... 4
Antibacterial activity of sele... 4
Multiplex ligation dependent p... 3
Expanding PVL positive MRSA He... 3
The utility of molecular genet... 3

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 23(4)/2015 DOI:10.1515/rrlm-2015-0041
XML
TXT

Research article

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Laszlo Hadadi, Ioana Sus, Eva Katalin Lakatos, Razvan Constantin Serban, Alina Scridon, Zoltan Demjen, Dan Dobreanu


Abstract:

Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO- group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with CTO: 105.2 (75.86-159.1) compared to 137 (97-188.1), p<0.01. Receiver-operator characteristic curve analysis identified an area under the curve of 0.61 (95%CI=0.57-0.67, p< 0.01) for PLT/LYM in predicting the presence of a CTO, with a cut-off value at 97.73. Lower values than this were independent predictors of a CTO in multivariate logistic regression analysis, with an Odds Ratio of 2.2 (95%CI=1.15-4.20, p=0.02). Our results support the use of platelet indices and PLT/LYM as predictors of CTO in patients presenting with STEMI.

Keywords: acute myocardial infarction, chronic total occlusion, platelets, lymphocytes

Received: 21.7.2015
Accepted: 24.9.2015
Published: 12.11.2015

 
  PDF Download full text PDF
(586 KB)
     
 
How to cite
Hadadi L, Sus I, Lakatos EK, Serban RC, Scridon A, Demjen Z, et al. Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction. Rev Romana Med Lab. 2015;23(4):407-14. DOI:10.1515/rrlm-2015-0041