RRML - Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.493
Five Year Impact Factor 0.531
SNIP 0.373
JCI 0.17


Advanced search


Top 10 downloaded articles
- August 2022 -
 
Downregulation of hsa-miR-4328... 8
Romanian Review of Laboratory ... 7
Antibacterial Activity of Clov... 7
The Effect of Resveratrol on S... 6
Carbapenem resistance determin... 6
Writing a Scientific Paper in ... 5
COVID-19 associated coagulopat... 5
Non-inhibitory effects of the ... 5
SPP1 is a biomarker of cervica... 5
Elbow Septic Arthritis caused ... 5

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 22(4)/2014 DOI:10.2478/rrlm-2014-0043
XML
TXT

Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis

Anca Bacârea, Claudia Bănescu, Ioan Macarie, Judit Beáta Köpeczi, Bogdana Dorcioman


Abstract:

Very few cases of chronic lymphocytic leukemia (CLL) presenting with extreme hyperleukocytosis are reported in the literature. We describe the case of a 66 years old woman, with newly diagnosed CLL presenting with extreme hyperleukocytosis of 774.2 x 109/liter, Rai stage III and Binet stage C. The patient has no comorbidities and the CIRS score (cumulative illness rating scale) is well below 6, with normal creatinine clearance. Some other interesting aspects related with this case are the atypical immunophenotype, the expression of Cyclin D1, and the B hepatitis viral infection, which made her diagnosis and treatment challenging. The patient was tested for NOTCH1 mutation and it was positive. There is important evidence that NOTCH1 mutations are associated with rapidly progressive disease and resistance to treatment. The distinction of CLL from mantle cell lymphoma (MCL) is not always easy because some MCLs may mimic CLL clinically, histologically, and/or phenotypically. The hepatitis B prophylaxis for viral reactivation was not available an in the end the patient was treated only with fludarabine and cyclophosphamide, without rituximab. CD200 should be introduced in the routine panel for flow cytometry to distinguish CLL from mantle cell lymphoma and NOTCH1 mutation is associated with poor prognosis and should be evaluated at diagnosis. CLL with extreme hyperleukocytosis presentation is very rare and sometimes an atypical CLL may represent a diagnostic pitfall.

Keywords: CLL; extreme hyperleukocytosis; NOTCH1 mutation

Received: 26.8.2014
Accepted: 18.11.2014
Published: 1.12.2014

 
  PDF Download full text PDF
(1037 KB)
     
 
How to cite
Bacârea A, Bănescu C, Macarie I, Köpeczi JB, Dorcioman B. Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis. Rev Romana Med Lab. 2014;22(4):507-13. DOI:10.2478/rrlm-2014-0043