RRML - Interaction between lifestyle factors and the XRCC1, XPD, and XRCC3 genetic variations modulates the risk for sporadic colorectal cancer
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Nr. 22(1)/2014 DOI:10.2478/rrlm-2014-0002
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Interaction between lifestyle factors and the XRCC1, XPD, and XRCC3 genetic variations modulates the risk for sporadic colorectal cancer

Lucia Maria Procopciuc, Gelu Osian


Abstract:

Background: Genetic variations, such as those affecting DNA repair genes, could represent susceptibility factors for sporadic colorectal cancer (CRC) as a result of their interaction with environmental factors. Materials and methods: 80 female and 70 males patients diagnosed with sporadic CRC in the Surgical Clinic III Cluj were genotyped for Arg399Gln-XRCC1, Lys751Gln-XPD and Met241Thr-XRCC3 using PCR-RFLP methods. We also genotyped 100 females and 62 males, who formed the control group. Genotyping results were related to environmental risk factors, smoking habit and diet. Results: Male patients carriers of the Arg399Gln, Lys751Gln, Met241Thr had a 4.09 (95%CI[0.96-19.98],p=0.05)-fold, 5.95(95%CI[1.08-43.22],p=0.03)-fold and 3.73(95%CI[0.86-18.53],p=0.05)- fold significantly increased risk to develop sporadic CRC if they smoked. A significantly increased risk for CRC was observed in females and males with high daily fried red meat intake, carriers of the Arg399Gln (OR 2.77 95%CI [1.34-6.82],p=0.015 and OR 8.64 95%CI[2.67-29.14],p<0.001), Lys751Gln (OR 4.12 95%CI[1.37-12.74],p=0.007 and OR 5.06 95%CI[1.4-19.02],p=0.006), Met241Thr (OR5.92 95%CI[2.21-16.23],p<0.001 and OR 5.64 95%CI[1.52-21.7],p=0.022). Female patients with high fried red meat intake had a significantly higher risk to develop early-onset sporadic CRC if they were carriers of the Arg399Gln-XRCC1 (OR 5.14 95%CI[0.99-28.3],p=0.047), Thr241Met-XRCC3 (OR 6.67 95%CI[1.05-46.67],p=0.025) and Lys751Gln-XPD (OR 4.7 95%CI[0.99-23.32],p=0.034). Conclusions: In Romanians, the association between the mutated genotypes and environmental risk factors modulates the risk for sporadic CRC. Smoking in association with the Arg399Gln-XRCC1 genetic variation influences the early onset of sporadic colorectal cancer in females. Diet rich in fried red meat intake associated with Arg399Gln-XRCC1, Lys751Gln-XPD and Thr241Met- XRCC3 genetic variations significantly influences the early onset of sporadic colorectal cancer in females.

Keywords: Arg399Gln-XRCC1,Lys751Gln-XPD,Thr241Met-XRCC3,PCR-RFLP,environmental exposure,Romania

 
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How to cite
Procopciuc LM, Osian G. Interaction between lifestyle factors and the XRCC1, XPD, and XRCC3 genetic variations modulates the risk for sporadic colorectal cancer. Rev Romana Med Lab. 2014;22(1):129-41. DOI:10.2478/rrlm-2014-0002