RRML - A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2019): 0.945

Rejection rate (2020): 75%

Română English


Clarivate analytics (ISI) Impact factor


Advanced search


Top 10 downloaded articles
- April 2021 -
 
Predictors associated with inc... 17
The Role of MiR-124 in Bladder... 11
Prognostic value of serum lact... 8
Romanian Review of Laboratory ... 7
Difficult to treat Proteeae st... 7
The role of qSOFA score and bi... 7
Clinical and paraclinical aspe... 6
Extended panel of biomarkers f... 6
Molecular diagnostic of Ureapl... 6
Vaginal candidiasis in Konya a... 5

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 21(2)/2013 DOI:10.2478/rrlm-2013-0001
XML
TXT

A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers

Corina Roman-Filip, Aurelian Ungureanu, Dan Filip, Eugen Radu, Ioan Sorin Zaharie


Abstract:

Creutzfeldt – Jakob disease (CJD) is a rare neurodegenerative disease caused by prions, characterized by a progressive dementia with rapid onset, psychiatric and neurologic symptoms (myoclonus, cerebellar, pyramidal, extrapyramidal and visual signs), with an invariable course to exitus. There are three general forms: sporadic or spontaneous, genetic or familial, and acquired form, including a variant form of CJD. The diagnosis can be confirmed only by histological examination of brain tissue, showing non-inflammatory spongiform changes and neuronal loss. We present the case of a 64 years old male who was admitted in our department for a rapidly progressive cognitive decline, hallucinations and myoclonus. Autopsy brain histology confirmed the diagnosis showing incipient spongiform vacuolization and astrogliosis. This paper illustrates a very rapid course of a sporadic CJD with discussion upon literature regarding the laboratory and pathology biomarkers of diagnosis.

Keywords: Creutzfeldt – Jakob disease,prions,biomarkers

 
  PDF Download full text PDF
(268 KB)
     
 
How to cite
Roman-Filip C, Ungureanu A, Filip D, Radu E, Zaharie IS. A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers. Rev Romana Med Lab. 2013;21(2):225-30. DOI:10.2478/rrlm-2013-0001