RRML - Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates

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Nr. 21(1)/2013 DOI:10.2478/rrlm-2013-0022

Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates

Mihaela I. Ionescu, Adriana Z. Costache, Ovidiu Oniga, HoriaL. Banciu, Iulia Lupan

Abstract:

Adenylat kinase is an ubiquitous enzyme found in prokaryotes and eukaryotes. In the present study we examined the inhibition of Streptococcus pneumoniae adenylate kinase (AKSP) by six 5-arylidene-thiazolidin-4-on-2-thione derivates using 2, 4-dinitrophenylhydrazine colorimetric assay. Inhibition of AKSP activity with synthetic compounds was performed against recombinant enzyme over-expressed in E. coli. The compound C10H6BrNOS2 with the bromine atom in –ortho position has shown the most efficient inhibitory activity; I50 value (the inhibitor concentration that leads to 50% activity inhibition) was 0.067mM.

Keywords: adenylate kinase,5-arylidene-thiazolidin-4-on-2-thione derivates,inhibitory activity

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Ionescu MI, Costache AZ, Oniga O, Banciu H, Lupan I. Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates. Rev Romana Med Lab. 2013;21(1):93-9. DOI:10.2478/rrlm-2013-0022