RRML - The protective role of polyphenols on blood cells in rats exposed to lead
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- September 2019 -
 
Romanian Review of Laboratory ... 11
The Value of FLT3, NPM1 and DN... 11
Genotype comparison of Candida... 11
Simultaneous FLT3, NPM1 and DN... 9
Antiphospholipid syndrome – ... 9
Antibacterial activity of sele... 8
Vascular impact of quercetin a... 7
Seroprevalence and risk factor... 5
Mutational spectrum and genoty... 5
FLT-3 ITD Positive Acute Basop... 4

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 20(3)/2012
XML
TXT

The protective role of polyphenols on blood cells in rats exposed to lead

Devrim Sarıpınar Aksu, Mustafa Didin, Fatma Kayikci


Abstract:

The present study investigated the protective potential of the polyphenols in pomegranate juice against the detrimental effects of lead exposure on the hematological system and antioxidant parameters of rat red blood cells. Forty adult male Sprague Dawley rats weighing about 300 g were allocated randomly to four groups: a control group that received normal food and water; a positive control group that received a daily dose of 2000 ppm lead (as lead acetate) in their drinking water for 5 weeks; a low treatment group that received a daily dose of 2000 ppm lead together with 30µl pomegranate juice (PJ; equivalent to 1050 µmol total polyphenols) by gavages for 5 weeks; and a high treatment group that received 2000 ppm lead and 60µl PJ (equivalent to 2100 µmol total polyphenols) daily for 5 weeks. The plasma lead level was significantly (p<0.001) decreased as the plasma copper and zinc levels were significantly increased (p<0.001) in rats received PJ. Significant increases (p<0.001) in red blood cell (RBC) and white blood cell (WBC) counts, and haemoglobin (Hb) and packet cell volume (PCV) were found in both PJ groups compared to the rats exposed to lead alone. Rats that received PJ in addition to lead showed erythrocyte glutathione and plasma ceruloplasmin levels and erythrocyte superoxide dismutase and catalase activities that were almost close to the control values. These observations indicated that treatment of rats with polyphenols might have produced amelioration in hematological system of rats exposed to lead, protecting the level of copper, zinc and antioxidants by against lead induced damage in blood cells.

Keywords: Lead,polyphenols,pomegranate juice,oxidative stress,blood cell,rat

 
  PDF Download full text PDF
(349 KB)
     
 
How to cite
Aksu DS, Didin M, Kayikci F. The protective role of polyphenols on blood cells in rats exposed to lead. Rev Romana Med Lab. 2012;20(3):233-43